细胞间粘附分子-1和血管细胞粘附分子-1在慢性排斥反应中的表达

Expression of ICAM 1 and VCAM 1 in human chronic renal allograft rejection

为了探讨移植肾慢性排斥反应的发病机制，应用免疫组化技术（ＡＢＣ法）对１６例肾移植术后发生慢性排斥反应患者的移植肾组织及５例正常肾组织行细胞间粘附分子－１（ＩＣＡＭ－１）、血管细胞粘附分子－１（ＶＣＡＭ－１）染色及ＨＥ染色。结果表明ＩＣＡＭ－１、ＶＣＡＭ－１在正常肾脏和慢性排斥反应移植肾脏上的表达分布不同；结果提示，它们在移植肾慢性排斥反应的发生。

To study the mechanism of human chronic renal allograft rejection, kidney tissues were taken from 16 patients with chronic renal allograft rejection and from 5 healthy subjects, and underwent the frazed section staining for ICAM 1 and VCAM 1 to anti ICAM 1 and anti VCAM 1 respectively by using immunohistochemistry (ABC). The results showed that there were different distribution of ICAM 1 and VCAM 1 expression in nomal kidney and renal allograft during chronic rejection. It was suggested that ICAM 1 and VCAM 1 might play an important role in the pathogenesis of human chronic renal allograft rejection.