黄连配伍黄芩、甘草对实验性G6PD缺陷大鼠红细胞渗透脆性的影响

Influence of Huanglian Used in Combination with Huangqin and Gancao on the Erythrocytic Osmotic Fragilitas of Experimental Glucose 6 Phosphate Dehydrogenase(G6PD)Deficiency in Rats

目的：研究常用黄连配伍对Ｇ６ＰＤ缺陷大鼠红细胞渗透脆性的影响。方法：将黄连与黄芩、甘草配伍的各种合煎液通过灌胃给药途径，应用至Ｇ６ＰＤ缺陷大鼠模型中，检测其红细胞渗透脆性的变化。结果：黄连配伍后，红细胞渗透脆性均低于或等于单用黄连（甚至不用黄连）的水平。脆性降低程度与配伍药物、剂量、比例有关。结论：黄连和黄芩、甘草适当配伍，对降低Ｇ６ＰＤ缺陷大鼠红细胞渗透脆性有一定意义。

Objective:To study the influence of common combination of Huanglian(Coptis chinensis)on the erythrocytic osmotic fragilitas of glucose 6 phosphate dehydrogenase(G6PD)deficiency in rats.Method:Various decoctions with Huanglian mixed with Huangqin (Scutellaria baicalensis)and Gancao(Glycyrrhiza uralensis)were orally administered to the G6PD deficiency rat model,and the erythrocytic osmotic fragilitas was measured.Result:The erythrocytic osmotic fragilitas after the combined use of Huanglian appears lower than (or equal to)that of Huanglian used alone(or even not used).The fragilitas lowers depending largely on the medicine in combination,dosage and proportion.Conclusion:Proper use of Huanglian in combination with Huangqin and Gancao is of some significance in lowering the erythrocytic osmotic fragilitas of G6PD deficiency in rats.