中药补益方对高压氧致急性氧中毒预防作用的实验研究

Experimental Study on Preventive Effect of Traditional Chinese Medicine Replenishing Recipe on Acute Oxygen Toxicity Caused by Hyperbaric Oxygen

目的 :寻找能够有效对抗氧惊厥发生的中药复方 ,为用中药复方预防氧惊厥提供一定根据。方法 :选择补益类方剂中具有代表性作用的方剂灌胃给药 ,然后观察氧惊厥发生的潜伏期和惊厥后肺、脑组织中超氧化物歧化酶 (SOD)活性。结果 :与对照组比较 ,四君子汤组氧惊厥发生潜伏期明显延长 (P <0 0 1 ) ,四物汤组、六味地黄汤组和人参地黄汤组潜伏期明显缩短 (P <0 0 1 ) ;惊厥后四君子汤组肺组织中SOD活性明显升高 (P <0 0 1 ) ,六味地黄汤组脑组织中SOD活性升高 (P <0 0 5 )。结论 :补益类中药方剂中 ,具有健脾益气作用的四君子汤对于氧惊厥的发生有一定的对抗作用。

Objective: To seek for the effective traditional Chinese medicine (TCM) replenishing recipe (RR) prescription that being able to prevent the onset of oxygen convulsion and to offer some clues in preventing the oxygen convulsion with TCM RR. Methods: Mice were administered orally with four respective representative RR, Sijunzi Decoction, Siwu Decoction, Liuwei Dihuang Decoction, and Renshen Dihuang Decoction. Then the convulsion latent periods were recorded and SOD vitalities in brain and lung were determined. Results: Compared with the control groups, the convulsion latent period of Sijunzi Decoction group was prolonged significantly (P<0 01) and its SOD vitality in lung was maintained higher (P<0 01) after convulsion, while the other three RR results have no significant difference (P<0 05). Conclusion: Sijunzi Decoction has certain preventive effect on acute oxygen convulsion.