摘要
目的:了解HLAB27在强直性脊柱炎(AS)发病及病情活动中的作用。方法:对比分析51例HLAB27阴性〔B27(-)〕AS患者和102例病程相同的HLAB27阳性〔B27(+)〕AS患者(1∶2配对)的临床表现及实验室检查结果。结果:B27(-)组与B27(+)组最明显的差异是前者以女性多见,平均发病年龄偏晚(P值分别<001和005),且临床上较少出现全身症状、外周关节炎及严重的髋关节病变(P均<005),但合并类风湿关节炎明显多于阳性组(P<001),家族聚集现象、虹膜睫状体炎和脊柱的X线片改变在两组无差异。病情活动性指标的改变包括血沉和C反应蛋白的升高在B27(-)组明显少于B27(+)组(P均<001)。结论:B27(-)AS患者病情相对较轻,预后较好;
Objective:To investigate the possible role of HLA B27 in the pathogenesis of ankylosing spondylitis (AS).Methods:The clinical and laboratory manifestations of 51 HLA B27 negative (-) patients with ankylosing spondylitis (AS) were analyzed and compared with those of 102 B27 positive (+) patients whose mean duration of disease was similar to those of the B27(-) patients.Results:The B27(-) group tended to have more females and had later onset of disease ( P <0 05 or <0 01).Fewer B27(-) patients developed constitutional symptoms,peripheral arthritis and severe destructive lesions in hip joints ( P <0 05).However,the B27(-) patients were more frequently associated with rheumatoid arthritis ( P <0 01).There was no significant difference in familial aggregation,acute anterior uveitis and X ray“bamboo spine”lesions between two groups.The parameters of disease activity were increased less significantly in B27(-) patients than those in B27(+) patients.Conclusion:B27(-) AS patients have mild symptoms and favorable prognosis.B27(-) AS might have different pathogenesis compared to B27(+) AS.
出处
《中华风湿病学杂志》
CAS
CSCD
1998年第3期143-146,共4页
Chinese Journal of Rheumatology
关键词
HLA-B27抗原
强直性脊柱炎
HLA B27 antigen spondylitis,ankylosing comparative study