冠状动脉粥样硬化斑块与幽门螺杆菌的关系

目的检测冠状动脉粥样硬化斑块中是否存在幽门螺杆菌,并比较同一患者动脉粥样硬化斑块及其胃黏膜中的幽门螺杆菌的一致性,以探讨冠心病与幽门螺杆菌之间可能的关系。方法选择31例行冠状动脉搭桥术的患者,术前及术后分别收集胃黏膜下幽门螺杆菌和冠状动脉粥样硬化斑块,采用幽门螺杆菌特异性引物,通过聚合酶链反应(PCR)技术,检测粥样硬化斑块及胃黏膜中幽门螺杆菌的DNA并对扩增产物进行测序分析。结果31例冠状动脉粥样硬化斑块中H.pylori的阳性27%,H.fennelliaede的阳性率45%,H.cinaedi的阳性率28%,31例胃黏膜中幽门螺杆菌H.pylori的阳性率27%,H.fennelliaede的阳性率45%,H.cinaedi的阳性率28%。16例患者同时在动脉粥样硬化斑块及其胃黏膜中检测出幽门螺杆菌。结论冠状动脉粥样硬化斑块中存在幽门螺杆菌,幽门螺杆菌在冠状动脉粥样硬化发生、发展过程中起一定的作用,可能与冠心病发病有关。

Objective The aim of this study was to observe the coexistence of periodontal bacteria DNA in coronary athermomatous plaques in patients scheduled for Helicobacter pylori. Methods Selected 31 of the patients with coronary artery bypass grafting, Respectively, gastric Helicobacter pylori and coronary atherosclerotic plaque were collected before and after the operation, detected the atherosclerotic plaque and gastric mucosa of Helicobacter pylori PCR products of DNA sequencing using the Helicobacter pylori using specific primers by polymerase chain reaction （PCR） technology. Results In 31 coronary atherosclerotic plaque, the H.pylori-positive was 27%, H.fennelliaede positive rate was 45%, H.cinaedi positive rate was 28%, in 31 Helicobacter pylori, gastric mucosa of H.pylori-positive rate was 27%, H.fennelliaede positive rate was 45%, H.cinaedi positive rate was 28%. At the same time, 16 patients with atherosclerotic plaque and its detection of Helicobacter pylori in gastric mucosa. Conclusions There were Helicobacter pylori in coronary atherosclerotic plaque, Helicobacter pylori played a role in the occurrence and development of coronary atherosclerosis, and may be related to coronary heart disease.