毛翅蝇变应性鼻炎病人血清特异性IgE,IgG亚类水平观察

Specific IgG and specific IgG subclass in allergic rhinitis

为了解毛翅蝇变应性鼻炎病人的免疫状态，观察60例毛翅蝇变应性鼻炎病人的总IgE，特异性IgE，总IgG及特异性IgG亚类水平。结果表明，病人组特异性IgE（30．60±0．78）明显高于对照组（0．64±0．16）（P＜0．001）；特异性IgG4水平病人组（383．31±96．48）与对照组（227．92±94．48）亦有极显著性差异（P＜0．001）；特异性IgG2病人组（365．46±109．32）与对照组（162．44±88．62）也有极显著性差异（P＜0．001）。免疫治疗后病人组特异性IgE水平下降（治疗前30．60±0．78，治疗后1．58±0．44），特异性IgG4水平也下降（治疗前383．31±96．48，治疗后233．68±80．94）均存在极显著性差异（P＜0．001）。提示特异性IgG亚类在Ⅰ型变态反应性疾病的诊断中，具有明显的特异性及敏感性。

Using enzyme-linked immunosorbent assay,we detected the levels of total IgE,cad-dis fly specific IgE and caddis fly specific IgG subclass in 60 patients with caddis fly allerglc rhini-tis. The results showed that the levels of SIgE (30. 60±0. 78) of patients were significantly higher than that of the controls (P <0.001 ). Same results were received in the levels of specific IgG2 and IgG4. The differences of specific IgE and specific IgG4 between the groups before treatment and af-ter treatment were also significant (Specific IgE before treatment: 30.60±0.78,after treatment:1. 58±0. 44, P<0.001; specific IgG4 before treatment: 383. 31±96. 48,after treatment: 233. 68±80. 94, P<0.001). We conclude that specific IgG subclass has obviously etiologic specificity and sensitivity.