孕期铅暴露对婴儿听觉发育影响的研究

目的:探讨孕妇孕期低水平铅暴露对婴儿听觉发育的可能影响。方法:2006～2007年在广州市天河区妇幼保健院对100例孕中期血铅水平的产妇所生新生儿至婴儿6月龄时行脑干听觉诱发电位(BAEP)检测,作为铅暴露对婴儿听功能影响的研究指标。结果:①听觉异常的婴儿占调查胎儿的12.0%;②产妇血铅水平越高,婴儿听觉异常的发生率随之增加。结论:铅对胎儿的听觉影响没有最低值,低水平铅暴露是导致新生婴儿听觉异常的主要原因之一。

Objective ： To investigate the probable effects of lead exposure during pregnancy on auditory development in infants. Methods： One hundred infants were selected and their mother＇s blood Pb levels in pregnant in second trimester were determined in 2006 - 2007, and Pb levels were determined as a marker to reflect lead expo-sure. BAEP was recorded in infants at 6 months of age as effective indicators to study effects of lead on their auditory development. Results： （1）The rate of dysaeousis in infants was 9.4% in the very low - level group , 14.6% in the low - level group and 20.0% in the high - level group respectively. （2）As the blood lead level of the pregnant increased, the rate of dysacousis in infants increased, even if is the low horizontal lead exposition group. Conclusions： As for the toxicity of lead to the fetus, there is no a threshold. Low level lead exposure of the pregnant woman is one of the causes of dys acousis in infants.