血管紧张素转换酶基因多态性与2型糖尿病肾病的关系

The Relationship between Insertion/Deletion Polymorphism of Angiotensin Converting Enzyme Gene and Diabetic Nephropathy in NIDDM Patients

为探讨血管紧张素转换酶（ＡＣＥ）基因多态性与２型糖尿病（非胰岛素依赖性糖尿病，ＮＩＤＤＭ）肾病之间的关系，应用ＰＣＲ方法检测１００例正常人和１５６例ＮＩＤＤＭ患者ＡＣＥ基因插入／缺失（Ｉ／Ｄ）多态性。ＮＩＤＤＭ患者中６１例合并肾病，９５例不伴肾病，同时对有关临床因素进行分析。结果发现ＮＩＤＤＭ肾病组缺失（ＤＤ）型的发生频率明显高于非肾病组及正常人（Ｐ＜０．０５，Ｐ＜０．０１），ＤＤ型与ＮＩＤＤＭ肾病的发生明显相关（ＯＲ１．６９，９５％可信限１．２１～２．６５）；ＮＩＤＤＭ患者ＤＤ型的血压较插入（Ｉ）型高。提示ＡＣＥ基因ＤＤ型ＮＩＤＤＭ患者易感肾病。

This study aims to investigate the relationship between insertion/deletion (I/D) polymorphism of angiotensin converting enzyme (ACE) gene and diabetic nephropathy(DN) in NIDDM patients. I/D polymorphyism was detected by polymerase chain reaction (PCR) in healthy control subjects and NIDDM patients, among whom 61 cases were accompanied with DN (UAE>20 μg/min) and 95 cases were not (UAE<20 μg/min). Results showed that the frequencies of D allel DD genotype were higher among DN group than among the control subjects ( P <0.01) and no DN group ( P <0.05). Delete polymorphism of ACE gene is associated with DN in NIDDM. It suggests that detecting I/D polymorphism of ACE is of help for preventing DN in NIDDM patients.