氨氯地平对高血压合并糖尿病患者降压疗效的临床研究

Antihypertensive Effects of Amlodipine in Patients with Essential Hypertension Complicated with Diabetes

采用安慰剂自身对照的临床试验法，观察氨氯地平（ＡＭ）对高血压（ＨＴ）及高血压合并糖尿病（ＥＨＣＤ）患者的降压疗效。主要应用诊室血压（ＣＢＰ）和动态血压监测（ＡＢＰＭ）方法比较ＡＭ对ＨＴ和ＥＨＣＤ的降压疗效、降压效应谷／峰比率（降压Ｔ／Ｐ）及不良反应。结果表明：Ｅ－ＨＣＤ组和ＨＴ组患者治疗后（治疗终点）ＣＢＰ显示总有效率均达１００％，组间比较差异无显著性。ＡＢＰＭ结果显示：两组药后血压负荷均降低，各时点血压较治疗前下降，可保持血压的昼夜时辰节律，降压Ｔ／Ｐ大于５０％，且不良反应低。提示每日１次ＡＭ可显著降低ＣＢＰ和ＡＢＰＭ血压。对轻、中度ＨＴ合并或不合并ＤＭ患者起到２４小时降压作用。

This 3 month placebo self controlled trial evaluated the antihypertensive effects of Amlodipine (AM) on mild to moderate essential hypertensive patients (HT) ( n =24) in comparison with essential hypertensive patients complicated with diabetes (EHCD) ( n =13). In order to compare the efficiency, trough to peak ratios (T/P) of the antihypertensive effect of AM in HT of EHCD patients, the clinical blood pressurs (CBP) and ambulatory blood pressure monitoring (ABPM) were observed. The results showed that the effective rate in both groups were 100% with no significant difference. The ambulatory recordings showed that AM maintained the diastolic and systolic pressure below baseline levels at every hour during the 24 h observation period and had no effect on the circadian rhythm of BP. The trough to peak ratios for SBP and DBP were both over 50%. It showed that once daily AM significantly lowered blood pressure during the present study. This effect was clearly demonstrated by both the 24 h post dosing readings and the 24 h ambulatory recordings. Once daily AM is clearly efficacious for the full 24 h period of the day and well tolerated in mild to moderate hypertensive patients with/or without diabetes.