摘要
对江苏省１９９７年糖尿病流行病学调查中，筛选出的糖尿病患者１８３例及与其性别、年龄构成相近的正常人对照１６４例，进行了２型糖尿病遗传和环境危险因素的病例对照研究。结果显示：病例组和对照组具有良好的均衡可比性，病例组一级亲属总的累积发病率为３．７６％，与对照组的１．１０％相比，差异有非常显著性（Ｐ＜０．００５）；２型糖尿病的遗传度为３６．２％；Ｌｏｇｉｓｔｉｃ回归分析表明，遗传因素与肥胖、高血压等危险因素共同存在时，糖尿病的发病危险性（ＯＲ）将显著增加。
A case control study on 183 cases and 164 controls was made in an epidemiological survey in 1997 in Jiangsu province, to explore genetic and envirenmental risk factors and their relationship in type 2 diabetes mellitus. The results showed that the average of age and sex ratio in both case and control groups were comparable. The total cumulative incidence rate of the first degree relatives in cases was 3.76%, being significantly higher than that in controls 1.10%( P <0.005). The heritability of type 2 diabetes mellitus was 36.2%. Logistic regression analysis showed that the relative risk of type 2 diabetes mellitus was significantly increased when both genetic and environmental risk factors such as obesity and hypertension were observed. It means that the development of type 2 diabetes mellitus results from both genetic and environmental risk factors.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
1998年第6期491-494,共4页
Journal of Nanjing Medical University(Natural Sciences)
基金
江苏省预防医学科研基金
关键词
糖尿病
危险因素
遗传
环境
流行病学
NIDDM
non insulin dependent diabetes mellitus
risk factors
heredity
environment
epidemiologic factors
Jiangsu province
