CPC/SF复合材料的制备

Preparation of calcium phosphate cement/silk fibroin composite materials

在磷酸钙骨水泥（CPC）粉末中加入丝素（SF）粉制备CPC/SF复合材料。用X射线衍射法、红外光谱法研究材料的结构,用ISO水泥标准维卡仪测定复合材料的凝固时间,用扫描电子显微镜观察材料的表面形态。结果表明,CPC粉末的主要成分为磷酸氢钙、磷酸四钙,在固化过程中磷酸氢钙转化为羟基磷灰石。当液固比相同时,丝素比例在0-3%范围内,在CPC粉末中加入SF粉制成复合材料的凝固时间随着丝素比例的增加而缩短;当丝素比例由3%增加到4%时,CPC/SF复合材料调制不匀,不具注射性。在本实验条件下,CPC中加入SF粉可增加骨水泥的抗弯强度。

Silk fibroin （SF） powder was added into calcium phosphate cement （CPC） powder to prepare CPC/ SF composite materials. The structure of materials was studied by X-ray diffraction and Fourier transform infrared spectroscopy. The setting time of the composite materials was investigated by ISO Cement Standard Consistency Instrument. The surface morphology was observed by SEM. The results showed that the CPC powder mainly consists of dicaleinm phosphate dehydrate （DCPD） and tetracaleium phosphate （TTCP）. DCPD changed into hydroxyapatite （HA） during the harden process. With the same of liquid-to-powder ratio, when the ratio of silk fibroin varied from 0 to 3 %, the setting time of the CPC/SF composite materials decreased with the increase of SF powder; when the ratio of SF powder increased from 3% to 4%, the CPC/SF composite materials were difficult to be mixed and impossible to be casted. The flexural strength of the cement increased when SF powder was added into CPC powder under this experimental conditions.