基于不同溶液体系载药纳米纤维膜的制备

Preparation of drug-loaded nanofiber membranes in different solution systems

以不同配比的丙酮与二氯甲烷为溶剂体系,选用不同黏均分子质量的左旋聚乳酸,通过改变药物的添加比例来调节纺丝溶液的性能,并运用扫描电镜分析静电纺纳米纤维膜的形貌,探求其与溶液性能之间的关系。结果表明:仅以丙酮为溶剂,因溶液体系黏度低而表面张力大,收集到的只是大量的珠子;以m(丙酮)∶m(二氯甲烷)=1∶2为溶剂,聚乳酸的分子质量为1×105,质量分数为10%时,制备的纤维无串珠且分布较好;向溶液中加入碱性药物克拉霉素时,成纤的聚乳酸质量分数相应减小,溶液的导电性能增加,收集到的纤维直径变细,分布变得混乱。

This properties of the molecular weight paper studies the relationship between the morphology of nanofiber membranes and the solution systems by and concentration of varying the ratio of PLLA and the drug 1 acetone and dichloromethane, viscosity-average oading. SEM is used to observe morphology of formed nanofiber membranes. The result shows that there are many beads in the collector because of low viscosity and big surface tension in the solvent of acetone ;if the ratio of acetone and dichloromethane is 1：2, viscosity-average molecular weight and mass fraction of PLLA is 1 × 10^5 and 10 percent respectively, the morphology of prepared nanofibers are very good and have no beads on surface; if some amount of alky clarithromycin are added, the concentration of PLLA reduces, the conduction of the solution increases, and the nanofibers＇ diameters become fine and confusing in distribution.