四川淫羊藿中两个新的黄酮醇苷

Chemical constituents of Epimedium sutchuenense

目的对四川淫羊藿Epimedium sutchuenense的化学成分进行研究。方法利用硅胶、聚酰胺、Sephadex LH-20、ODS等柱色谱进行分离和纯化，根据化合物的光谱学数据和理化方法鉴定其结构。结果从四川淫羊藿70％乙醇提取物中分离得到了10个化合物，鉴定其结构为川藿苷A（sutchuenoside A，D、川藿苷B（sutchuenoside B，Ⅱ）、大豆苷元（daidzein，Ⅲ）、宝藿苷-Ⅰ（baohuoside-Ⅰ，Ⅳ）、kaempferide 3-rhamnoside（Ⅴ）、淫羊藿苷（icariin，Ⅵ）、anhydroicaritin-3-O-α—L—rhamnopyranosyl（1→2）-α-L-rhamnopyranoside（Ⅶ）、对羟基苯甲酸（p-hydroxybenzoic acid，Ⅷ）、胡萝卜苷（daucosterol，Ⅸ）、β-谷甾醇（psitosterol，Ⅹ）。结论化合物Ⅰ和Ⅱ为新化合物，分别命名为sutchuenoside A和B，俗名为川藿苷A和B，化合物Ⅲ、Ⅴ、Ⅶ、Ⅷ～Ⅹ系首次从该植物中分离得到。

Objective To study the chemical constituents of Epimediurn sutchuenense. Methods The compounds were repeatedly separated and purified on column chromatography of silica gel, polyamide, Sephadex LH-20, and ODS. The structures were identified on the basis of spectral methods. Results Ten compounds were isolated from 70% ethanol extract of E. sutchuenense and were identified as sutchuenoside A （ Ⅰ ）, sutchuenoside B （ Ⅱ ）, daidzein （ Ⅲ ）, baohuoside- Ⅰ （Ⅳ）, kaempferide 3-rhamnoside （ Ⅴ ）, icariin （ Ⅵ ）, anhydroicaritin-3-O-α-L-rhamnopyranosyl （ 1 →2）-α-L-rhamnopyranoside （ Ⅶ ）, p-hydroxybenzoic acid （Ⅷ）, daucosterol （Ⅸ）, and β-sitosterol （ Ⅹ ）, respectively. Conclusion Compounds Ⅰ and Ⅱ are novel ones named as sutchuentins A and B respectively. Compounds Ⅲ , Ⅴ , Ⅶ, and Ⅷ-- Ⅹ are isolated from this plant for the first time.