陶瓷膜超滤精制制首乌颗粒药材提取液的工艺研究

Refining processing of Radix Polygoni Multiflori Granula with ceramic membranes

目的考察无机陶瓷膜在制首乌颗粒水提液精制过程中,不同孔径的膜对该体系的适用性,并进行膜过程优化设计。方法以制首乌水提液为研究对象,测定了3种不同孔径膜及不同操作参数下膜渗透通量及有效成分的变化等。结果50nm膜的膜渗透通量和二苯乙烯苷转移率均明显高于其他两种膜,应以操作压差0.8～1.2MPa,温度50～60℃、膜面流速3.0m/s作为大生产合适的滤过条件,当滤过液浓缩到原液体积1/10时,加入相同体积的去离子水,其有效成分转移率达80%以上,即可结束滤过,本系统采用强酸、强碱交替清洗的方法,可使膜通量恢复90%以上。结论采用无机陶瓷膜超滤技术精制制首乌颗粒是可行的适用技术,为陶瓷膜分离技术应用于中药水提液的精制提供了工艺技术参数及依据。

Objective To observe the effect of the different bore diameter membranes on technological parameters of Radix Polygoni Multiflori Granula and to optimize the process of membrane filtration. Methods Three different membranes were tested under different parameters of operation to observe the changes in membrane flux and the content of effective components by Radix Polygoni Multiflori Granula. Results The membrane （50 nm） had the great flux, the transfering rate of stilbene glucoside was the highest; The optimum conditions： the operation differential pressure was 0.8--1.2 MPa; The operation temperature was 50--60 ℃ ; the membrane surface flow rate was 3.0 m/s. When the volume of filtration solution was condensed to 1/10 of former, entering the same volume deionized water into it, and when the effective components transfering rate reached 80%, the filtration was finished. Using the strong acid and strong alkali to wash it in turn, the flux could revive above 90%. Conclusion It can be obtained a good result that adopts the technology of ceramic membranes microfiltration to refine Radix Polygoni Multiflori Granula. This can provide the foundation for the application of ceramic membrane microfiltration in the refinement of water extraction of other Chinese materia medica.