157例重度子痫前期临床特点分析

Clinical characteristics of severe pre-eclampsia in 157 cases

目的探讨早发型重度子痫前期一般临床特点及其引起的严重并发症情况。方法分析本院产科2007年4月1日～2008年10月30日住院的早发型(35例)和晚发型(122例)重度子痫前期患者的一般临床特点和严重并发症情况。结果重度子痫前期早发型组大量蛋白尿、血小板减少、胎盘早剥、HELLP综合征、胎儿生长受限、死胎的发生率均高于晚发型重度子痫前期组,差异有统计学意义(P<0.05)。结论早发型重度子痫前期组母胎并发症严重,更易引起母胎不良后果。

Objective To describe the clinical characteristics and complications of severe pre-eclampsia. Methods We retrospectively analyzed 157 women with severe pre-eclampsia enrolled from April 1,2007 to October 30, 2008. Severe pre-eclampsia cases included 35 early onset severe pre-eclampsia （24 W -34 W） and 122 late onset severe pre-eclampsia （34 W or greater）. We studied the general clinical characteristics and severe complications of mothers and fetus. Results Early onset pre-eclampsia was characterized by proteinuria （3 ＋ or above ） and lower platelet count. The complications of early onset preeclampsia, including placental abruption, HELLP （hemolysis, elevated liver enzymes and low platelets ）, fetal growth restriction, and fetal death, were significantly worse than these in late onset pre-eclampsia. Conclusion Early onset pre-eclampsia had more complications and were more severe, and the outcome of mother and fetus were poorer, compared with late onset pre-eclampsia.