吡格列酮对高糖诱导血管内皮细胞凋亡的影响及作用机制
被引量：2
Effects of pioglitazone on high glucose-induced vascular endothelial cell apoptosis and the involved mechanisms
摘要
吡格列酮可抑制高糖诱导的血管内皮细胞凋亡,其机制可能与抑制高糖诱导的酸性鞘磷酯酶活性升高,减少细胞内神经酰胺产生相关。
[Summary] Pioglitazone （Pio） attenuated high glucose-induced apoptosis in HUVECs in a concentration-dependent manner probably through its inhibition on intracellular acidic sphingomyelinase （A-Smase） and ceramide（CER）.
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2009年第9期709-710,共2页
Chinese Journal of Diabetes
关键词
吡格列酮
葡萄糖
内皮细胞
凋亡
神经酰胺
鞘磷酯酶
Pioglitazone
Glucose
Endothelial cells
Apoptosis
Ceramide
Sphingomyelinase
参考文献6
-
1Minamikawa J, Tanaka S, Yamauehi M,et al. Potent inhibitory effect of troglitazone on carotid arterial wall thickness in type 2 diabetes. J Clin Endocrinol Metab, 1998,83 : 1818-1820.
-
2Lupi R, Dotta F, Marselli L, et al. Prolonged exposure to free fatty acids has cytostatie and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated. Diabetes, 2002, 51 : 1437-1442.
-
3Straczkowski M, Kowalska I, Nikolajuk A, et al. Relationship between insulin sensitivity and sphingomyelin signaling pathway in human skeletal muscle. Diabetes, 2004, 53 : 1215-1221.
-
4童南伟,万沁,刘小菁,吴惠.吡格列酮对内皮细胞功能影响及其机制的体外研究[J].四川大学学报（医学版）,2005,36(4):525-528. 被引量：1
-
5Mano N, Oda Y, Yamada K,et al. Simultaneous quantitative determination method for sphingolipid metabolites by liquid chromatography/ionspray ionization tandem mass spec-trometry. Anal Bioehem, 1997,244 : 291-300.
-
6He X, Chen F, Dagan A,et al. A fluorescence-based, high-performance liquid chromatogramphic assay to determine acid sphingomyelinase activity and diagnose types A and B Niemann-Pick disease. Anal Biochem, 2003,314 : 116-120.
二级参考文献8
-
1Van Oostrom AJ, Cabezas MC, Rabelink TJ. Insulin resistance and vessel endothelial function. J R Soc Med,2002;95(Suppl 42):54.
-
2Booth G, Stalker TJ, Lefer AM, et al. Mechanisms of amelioration of glucose-induced endothelial dysfunction following inhibition of protein kinase C in vivo. Diabetes,2002;51(5):1556.
-
3Omi H, Okayama N, Shimizu M, et al. Participation of high glucose concentrations in neutrophil adhesion and surface expression of adhesion molecules on cultured human endothelial cells: effect of antidiabetic medicines. J Diabetes Complications,2002;16(3):201.
-
4Morigi M, Angioletti S, Imberti B, et al. Leukocyte-endothelial interaction is augmented by high glucose concentrations and hyperglycemia in a NF-κB-dependent fashion. Journal of Clinical Investigation,1998;101(2):1905.
-
5Gliki G, Abu-Ghazaleh R, Jezequel S, et al. Vascular endothelial growth factor-induced prostacyclin production is mediated by a protein kinase C (PKC)-dependent activation of extracellular signal-regulated protein kinases 1 and 2 involving PKC-delta and by mobilization of intracellular Ca2+. Biochem J,2001;353(Pt 3):503.
-
6Obara K, Koide M, Ishikawa T, et al. Protein kinase C delta but not PKC epsilon activity is involved in contractile potentiation by endothelin-1 in the porcine coronary artery. J Cardiovasc Pharmacol,2000;36(5 Suppl 1):S120.
-
7Minami T, Abid MR, Zhang J, et al. Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein kinase C (PKC)-delta-NF-kappa B and PKC-zeta-GATA signaling pathways. J Biol Chem,2003;278(9):6976.
-
8Isshiki K, Haneda M, Koya D,et al. Thiazolidinedione compounds ameliorate glomerular dysfunction independent of their insulin-sensitizing action in diabetic rats. Diabetes,2000;49(6):1022.
同被引文献16
-
1Jing Wu,Min-Xiang Lei,et al.Rosiglitazone inhibits high glucose-induced apoptosis in human umbilical vein endothelial cells through the PI3K/Akt/eNOS pathway.Can.J.Physiol.Pharmacol.87:549–555 (2009).
-
2Jens Juul Holst,et al.The Physiology of Glucagon-like Peptide 1 Physiol Rev 87:1409-1439,2007.
-
3Thomas Nystr? M,Mark K.Gutniak,et al.Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease.Am J Physiol Endocrinol Metab 287:E1209–E1215,2004.
-
4Zhang,W.,Wang,R.,et al.Alpha-linolenic acid attenuates high glucose-in-duced apoptosis in cultured human umbilical vein endothelial cells via PI3K/Akt/eNOS pathway.Nutrition,23(10):762–770.
-
5Heiko A.Golpon,Annette Puechner,et al.Vasorelaxant effect of glucagon-like peptide-7-36 amide and amylin on the pulmonary circulation of the rat.Regulatory Peptides 102(2001) 81–86.
-
6Erdogdu,.,et al.,Exendin-4 stimulates proliferation of human coronary artery endothelial cells through eNOS-,PKA-and PI3K/Akt-dependent pathways and requires GLP-1 receptor.Mol.Cell.Endocrinol.(2010).
-
7Bugge A, Siersbaek M, Madsen MS, et al. A novel iaatronic peroxisome proliferator-activated receptor gamma enhan- cer in the uncoupling protein (UCP) 3 gene as a regulator of both UCP2 and 3 expression in adipocytes[J~. J Biol Chem,2010,285 (23) :17310-17317.
-
8Ma S,Ma L,Yang D,et al. Uncoupling protein 2 ablation exacerbates high-salt intake-indueed vascular dysfunction I-J3. Am J Hypertens,2010,23(8) :822-828.
-
9Sasaki S, Inoguehi T. The role of oxidative stress in the pathogenesis of diabetic vascular eomlicationsEJ-l. Diabe- tes Metab J,2012,36(4) :255-261.
-
10赵宏,刘国良,丁丽颖,王秋月.酰基化ghrelin通过PI3K/Akt通路抑制高糖诱导的内皮细胞凋亡[J].中国糖尿病杂志,2009,17(3):225-227. 被引量：4
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-
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-
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-
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