感染幽门螺杆菌的慢性萎缩性胃炎患者血清hs-CRP水平及其与Cag-A的关系

Serum Levels of High-Sensitivity C-Reactive Protein(hs-CRP)of Patients with Chronic Atrophic Gastritis(CAG) Due to Heplicobacter pylori Infection and Its Association with Bacterial CagA Virulence Factor

目的:探讨感染幽门螺杆菌(HP)的慢性萎缩性胃炎(CAG)患者血清超敏C-反应蛋白(hs-CRP)水平及其与HP细胞毒素相关基因CagA的关系。方法:以ELISA法检测CAG组患者血清hs-CRP水平和CagA-IgG,并与无临床症状(AS)感染者及健康对照者进行比较。结果:CAG组血清hs-CRP平均值(1.30±0.34)mg/L明显高于AS组(0.19±0.03)mg/L和健康对照组(0.11±0.03)mg/L(P均<0.01),AS组血清hs-CRP平均值显著高于对照组(P<0.05);CAG组CagA+HP与CagA-HP患者之间血清hs-CRP水平无明显差异,AS组CagA+HP与CagA-HP入选者之间血清hs-CRP水平亦无明显差异。结论:CAG组与AS组血清hs-CRP水平明显高于对照组。尽管HP感染可导致血清hs-CRP水平升高,但与是否表达CagA无关。

Objective：To investigate the serum concentrations of hs CRP of patients with chronic atrophic gastri tis （CAG） dur to H. pylori infection,and its association with bacterial virulence factor CagA. Methods ：Serum concentrations of hs CRP and Cag-IgG of patients with CAG were measured by use of an ELISA method ,and compared with them in H. pylon infected asymptomatie（AS） carriers,and a healthy control group, Results：The mean serum level of hs-CRP in all patients with CAG （1.30±0.34） mg/L was significantly higher than that in all AS subjects（0.19±0.03） mg/L and the healthy uninfected control group （0.11±0.03） mg/L（P〈0.01）.Moreover,the mean serum level of hs-CRP in the AS group was significantly higher than that observed in the uninfected control group（P〈0.05）. No significantly dif- ference was observed between mean serum level of hs CRP in patients with CAG with positive test for anti-CagA antibody and negative test for anti-CagA antibody. Moreover,mean serum levels of hs CRP were similar in AS subjects with positive test for anti-CagA and in those who were negative for anti-CagA antibody. Conclusion： The mean serum concentration of hs-CRP in patients with CAG and in AS carriers are higher than in a healthy control group. Although H. pylori infected is associated with higher serum levels of hs-CRP,serum concentrations of this inflammatory marker are not affected by expression of bacterial CagA virulence factor.