宫颈癌组织中VEGF的表达及意义

Expression and role of VEGF in cervical carcinoma

目的:研究血管内皮生长因子(VEGF)在宫颈癌组织中的表达特点及其意义。方法:免疫组化法检测VEGF在20例宫颈正常上皮、25例上皮不典型增生、45例宫颈癌组织中的表达特点及其相关性。结果:VEGF的表达随上皮病变程度的增高而逐渐增强,宫颈癌组织中VEGF表达明显高于正常组织(P<0.05);伴淋巴结转移者表达明显高于未转移者。结论:VEGF的过表达可能在宫颈癌变过程中发挥重要作用,并可作为宫颈癌转移的重要指标。

Objective： To investigate the expression and role of vascular endothelial growth factor （VEGF） in cervical carcinoma tissue. Methods： Immunohistochemistry method was used to detect the expression of VEGF in normal cervical epithelium （n = 20）, dysplasia epithelia hyperplasia （n = 25） and cervical carcinoma （n = 45）. Results： The positive expression of VEGF increased with epithelium malignant transformation. VEGF expression was significantly higher in tumor than in normal tissue respectively （P〈0. 05）. Expression of VEGF in cases with lymph node metastasis was higher than without lymph node metastasis （P〈0. 05）. Conclusion： The overexpression of VEGF plays an important role in development of cervical carcinoma. VEGF is a marker of cervical carcinoma metastasis. [Key words] vascular endothelial cell growth factor, cervical carcinoma, immunohistochemistry