胰岛素样生长因子-1受体、血管内皮生长因子C因子在食管鳞癌中的表达及意义

Expression of IGF-1R and VEGF-C in Esophageal Squamous Cell Carcinoma and their Significance

目的探讨胰岛素样生长因子-1受体(IGF-1R)、血管内皮生长因子C因子(VEGF-C)在食管鳞癌中的表达及其意义。方法应用免疫组化法(Envision二步法)检测95例食管鳞癌和40例癌旁组织中IGF-1R、VEGF-C的表达水平,并分析其表达与病理学意义。结果IGF-1R、VEGF-C在食管鳞癌组织中的检出率分别为81.05%(77/95),67.37%(64/95),在癌旁组织中的阳性检出率分别为20%(8/40),5%(2/40),差别均有统计学意义(P<0.01)。IGF-1R的阳性表达与食管鳞癌淋巴结转、组织分化程度、浸润深度有关(P<0.01);VEGF-C的阳性表达与食管鳞癌淋巴结转移、浸润深度有关(P<0.01),而与分化程度无相关性(P>0.05)。食管鳞癌中IGF-1R与VEGF-C间存在正相关(P<0.05)。结论IGF-1R、VEGF-C的异常表达在食管鳞癌发生、发展过程中具有重要作用,联合检测IGF-1R和VEGF-C的异常表达对肿瘤恶性程度、治疗及预后判定具有重要意义。

Objective To investigate the relationship between the expression of IGF-1R and VEGF-C and their clinical parameters of Esophageal Squamous Cell Carcinoma（ESCC）. Methods The expression of IGF-1R and VEGF-C on paraffin embedded tumor tissues from 95 ESCC patients and 40 non-cancer tissues were detected by immunohistochemistry （Envision）. Results The positive rates of IGF-IR and VEGF-C in ESCC were 81.05 %（77/95） and 67.37 %（64/95） respectively. And the expression of those in non-cancer was 20.00% （8/40） and 5.00% （2/40）. There was statistical significance between cancer and non- cancer groups（P〈0.01）. The expression rate of IGF-1R was strongly associated with the metastasis in lymph node, histological grade and depth of invasion of ESCC（P〈0.01）. The expression rate of VEGF-C was strongly associated with the metastasis in lymph node and depth of invasion of ESCC（P〈0.01）. However, no significant relationship was found between the expression of VEGF-C and histological grade（P〉0.05）. Significant relationship was found between IGF-IR and VEGF-C （P〈0.05）. Conclusion The abnormal expression of IGF-1R and VEGF-C may be the important factors in etiopathogenesis of ESCC. Expression of IGF-1 R and VEGF-C could be used as important biological indices for evaluating the malignant degree of ESCC. Combined determination of IGF-1R and VEGF-C expression has important clinical significance.