氟哌啶醇与昂丹司琼预防手术后恶心呕吐的比较

背景氟哌啶醇可以预防手术后恶心、呕吐（PONV），但是没有其与5-HT，拮抗剂的比较结果。方法随机选取244例成年患者，全麻过程中静脉给予氰哌啶醇1mg或者昂丹司琼4mg。通过处于盲态的第3方对恶心、呕吐、需要止吐治疗、镇静、锥体束外的效应、QTC间期以及离开麻醉恢复室的时间进行评估。结果组间不存在药效和药物毒性的差异。氟哌啶醇与昂丹司琼的有效率分别为78．2％和76．8％。手术后QTC间期延长的发生率分别为28．9％和22．1％（差异无显著性）。结论在各类手术的人群中，1mg氟哌啶醇和4mg昂丹司琼对预防PONV的效果和毒性没有显著的差别。

BAG（GROUND： Haloperidol is effective for postoperative nausea and vomiting prophylaxis, but there are almost no data comparing it to 5-HT3 antagonists. METHODS： Two hundred forty-four adults were randomized to receive IV haloperidol 1 mg or ondansetron 4 mg, during general anesthesia. Nausea, vomiting, need for rescue, sedation, extrapyramidal effects, QTc intervals, and time to postanesthesia care unit discharge were evaluated with a third-party blind design. RESULTS： There was no intergroup difference in any measure of efficacy or toxicity. Haloperidol and ondansetron subjects （78.2% and 76. 8%） had complete response. Postoperatively, prolonged QTc occurred in 28. 9% and 22. 1% （N. S,）. CONCLUSIONS： In a mixed surgical population, the efficacy and toxicity of postoperative nausea and vomiting prophylaxis with haloperidol 1 mg was not significantly different from ondansetron 4mg.