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TRAIL在肿瘤治疗中的敏感性调节

Sensitivity regulation of TRAIL in tumor therapy
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摘要 肿瘤坏死因子相关凋亡诱导配体(TRAIL)是肿瘤坏死因子超家族成员。TRAIL可与死亡受体DR4、DR5结合,通过触发胱天蛋白酶通路诱导肿瘤细胞凋亡。诱骗受体可与死亡受体竞争结合TRAIL,从而抑制TRAIL的凋亡活性。NF-κB和Bcl-2家族可作为TRAIL敏感性调节的重要靶点。 TNF related apoptosis inducing ligand （TRAIL） is one member of TNF superfamily. TRAIL triggers tumors cell apoptosis via ＂caspase＂ pathway, by binding to death receptors DR4 and DR5. DcR1 and DcR2 also bind to TRAIL to compete with DR4 or DR5 and inhibit apoptosis induced by TRAIL. NF-κB and Bcl-2 family can be targeted to regulate the sensitivity of TRAIL.
作者 杨玉鹤 孙铭娟 王梁华 焦炳华
机构地区 第二军医大学研究生管理大队学员七队 第二军医大学基础部生物化学与分子生物学教研室
出处 《生命的化学》 CAS CSCD 北大核心 2009年第5期654-657,共4页 Chemistry of Life
关键词 TRAIL 肿瘤细胞 抗药性 死亡受体 NF-ΚB BCL-2家族 TRAIL tumor cell death receptor NF-κB Bcl-2 family
分类号 R730.54 [医药卫生—肿瘤]
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生命的化学
2009年 第5期

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