期刊文献+

交感神经递质对肝星状细胞生物学特性的影响 被引量:1

下载PDF
导出
摘要 肝纤维化是慢性肝损伤后的修复反应过程,肝硬化是肝纤维化的最终发展阶段。目前研究表明,肝纤维化发生的中心环节是肝星状细胞(HSCs)的增生和激活。激活后的HSCs产生大量以胶原为主的细胞外基质(ECM)成分和细胞因子(CK)。本综述以肝星状细胞为中心,重点阐述交感神经递质对肝星状细胞生物学特性的影响及其机制的研究进展。
出处 《现代医药卫生》 2009年第21期3283-3285,共3页 Journal of Modern Medicine & Health
  • 相关文献

参考文献21

  • 1Senoo H.Structure and function of hepatic stellate cells [J].Med Electron Microsc, 2004,37(1):3.
  • 2Jungermann K, Sttlmpel F. Role of hepatic,intrabepatie and hepatoenteral nerves in the regulation of carbohydrate metabolism and hemodynamies of the liver and intestine [J].hepatogasoenterology, 1999,46(Suppl 2) : 1414.
  • 3Stoyanova II, Gulubova MV.Peptidergic nerve fibres in the human liver [J].Acta Histochem, 1998,10(3):245.
  • 4Villanueva I, Pi on M.Epinephrine and dopamine colocalization with norepinephrine in various peripheral tissues: guanethidine effects [J].Life Sci, 2003,73(13) : 1645.
  • 5Akiyoshi H,Gonda T,Terada T.A.Comparative histochemical and immunohistochemical study of aminergic, cholinergic and peptidergic innervation in rat,hamster, guinea pig,dog and human[J].Liver, 1998,18(5):352.
  • 6Mundinger TO ,Verchere CB ,Baskin DG,et al.Galanin is localized in sympathetic neurons of the dog liver[J].Am Physiol, 1997,273(6): E1194.
  • 7FukudaY,ImotoM, KoyamaY, et al.Demonstration of noradrenaline-immunoreactive nerve fibers in the liver[J].Int Med Res, 1996,24(6): 466.
  • 8Bhathal PS,Grossman H.Nerve supply and nervous control of liverfunction.In:Bircher J, Benhamou JP, McIntyre N, et al.In:Oxford textbook of clinical hepatology, 2nd edn[M].London:Oxford Medical Publi-cations, 1999.165.
  • 9Oben JA, Roskams T, Yang S, et al.Hepatic fibrogenesis requires sympathetic neurotransmitters[J].Gut, 2004,53:438.
  • 10Sancho-Bin P, Bataller R, Colmenero J,et al.Norepinephrine induces calcium spikes and proinflammatory actiorls in human hepatic stellate cells[J].Am J Physiol Gastrointest Liver Physiol,2006, 291 : G877.

二级参考文献23

  • 1Oben J, Roskams T, Diehl A, et al. Hepatic fibrogenesis requires sympathetic neurotransmitters [ J ]. Gut, 2004, 53 (3) : 438 -445.
  • 2Mancia G, Bousquet P, Elghozi J, et al. The sympathetic nervous system and the metabolic syndrome [ J]. J Hypertens,2007, 25(5): 909-920.
  • 3Henderson N, Iredale J. Liver fibrosis: cellular mechanisms of progressian and resolution [ J ]. Clin Sci , 2007, 112(5) : 265 -280.
  • 4Cassiman D, Denef C, Desmet V, et al. Human and rat hepatic stellate cells express neurotrophins and neurotrophin receptors [J]. Hepatology, 2001, 33(1 ) : 148 - 158.
  • 5Oben J, Yang Shiqi, Lin Huizhi, et al. Norepinephrine and neuropeptide Y promote proliferation and collagen gene expression of hepatic myofibroblastic stellate cells [ J ]. Biochem Biophys Res Commun, 2003, 302(4) : 685 -690.
  • 6Elsharkawy A, Oakley F, Mann D. The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis [J]. Apoptosis, 2005, 10(5): 927-939.
  • 7Remondino A, Kwon S, Communal C, et al. Beta-Adrenergic receptor-Astimulated apoptosis in cardiac myocytes is mediated by reactive oxygen species/c-AJun NH2-Aterminal kinase-Adependent activation of the mitochondrial pathway [J]. Circ Res, 2003, 92(2): 136- 138.
  • 8Safadi R, Friedman SL. Hepatic fibrosis-role of hepatic stellate cell activation. Med Gen Med, 2002, 4: 27.
  • 9Uyama N, Geerts A, Reynaert H. Neural connections between the hypothalamus and the liver. Anat Rec A Discov Mol Cell Evol Biol, 2004, 280: 808-820.
  • 10Akiyoshi H, Gonda T, Terada T. A comparative histochemical and immunohistochemical study of aminergic, cholinergic and peptidergic innervation in rat, hamster, guinea pig, dog and human livers. Liver, 1998, 18:352-359.

共引文献11

同被引文献9

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部