摘要
目的研究P13K和基质金属蛋白酶-7（MMP-7）在食管鳞癌组织（ESCC）中的表达及其与食管鳞癌细胞发生、发展与转移的关系以及两者之间的相关性。方法应用免疫组织化学sP法检测24例正常食管黏膜、94例食管鳞癌组织中P13K和MMP-7的表达情况。结果食管癌组织中P13K和MMP-7的阳性表达率分别为71．28％（67／94）和52．13％（49／94），与正常食管黏膜组织阳性表达率4．17％（1／24）和0％（0／24）相比，差异均有统计学意义（P均〈0．01）；P13K蛋白的表达与食管癌细胞的分化程度、淋巴结转移、浸润深度及临床分期显著相关（P均〈0．01）；MMP-7表达率与淋巴结转移（P〈0．05）、分化程度（P〈O．05）、浸润深度（P〈0．01）和I临床分期（P〈0．05）等因素有关；P13K与MMP-7表达呈显著正相关（r=0．232，P=0．025）。结论P13K、MMP-7表达与食管癌发生、发展及侵袭转移有关。
Objective To study the expression of PI3K and MMP-7 in esophageal carcinoma and the relationship between the expression of PI3K and MMP-7 and carcinogenesis and progression of esophageal carcinoma. Methods PI3K and MMP-7 expression were detected in 24 normal esophageal mucosa,94 primary tumor tissues with SP immunohistochemistal method. Results There were significant differences of PI3K and MMP-7 expressions between esophageal carcinoma and normal mucosa epithelium （ all P 〈 0. 01 ） [ 71.28% （67/94） vs 4.17% （ 1/24 ） and 52.13% （49/94） vs 0% （0/24） ]. There were significant correlations between PI3K expression and the degrees of differentiation,invasive depth, clinical staging and the metastasis of lymph node （ all P 〈 0.01 ）. The positive expression rate of MMP-7 had the relationship with metastasis of lymph node （ P 〈 0.05 ） , the degrees of differentiation （ P 〈 0.05 ） invasive depth（ P 〈 0.01 ） , and clinical staging（ P 〈 0.05 ） . There was a positive relationship between PI3K and MMP-7 expression in this study （r = 0. 232 ,P = 0.025 ）. Conlusions PI3K and MMP-7 play an important roles in carcinogenesis and progression of esophageal carcinoma and can be used as valuable biomarkers to evaluate biological characteristics in esophageal squamous cell carcinoma.
出处
《中国综合临床》
2009年第10期1083-1085,共3页
Clinical Medicine of China
基金
河北省普通高等学校强势特色学科肿瘤学建设经费资助[冀教高（2005）52号]
河北卫生厅医学科研基金（2007118）
