摘要
2(5H)-呋喃酮化合物具有多种生物活性。以溴代2(5H)-呋喃酮为起始原料与三甲基硅基乙炔进行Sonogashira钯催化偶联反应得到3个炔基取代的2(5H)-呋喃酮化合物。对反应条件进行了研究,发现加入Pd(PPh3)2Cl2、CuI、Et3N的量分别为底物量的10%、2%、物质的量比为1.5时,室温反应10min,产率最高。以1HNMR、13CNMR、MS及HRMS对产物的结构进行了确认。
The 2（5H）-furanone compounds were found to have several kinds of bioactivities. The brominated 2 （5H）-furanones were used as starting materials to be coupled with trimethylsilyl acetylene via the Sonogashira coupling reaction, resulting in three alkynyl 2（5H）-furanone derivatives.The reaction conditions were investigated. The highest product yield was obtained when the reactions were performed by mixing 10% of Pd（PPh3）2Cl2 and 2% of Cul with the brominated 2（5H）-furanones and Et3N （based on the substrate） in the molar ratio of 1.5 mixed, followed -by stirring the mixture at room temperature for 10 rain. The products were characterized by ^l HNMR,^13CNMR and MS.
出处
《化学试剂》
CAS
CSCD
北大核心
2009年第9期677-678,704,共3页
Chemical Reagents
基金
国家自然科学基金资助项目(30572237)
