AlCl_3催化邻甲氧基苯胺与丙烯腈加成反应的研究

Study on addition reaction of 2-methoxyaniline upon acrylonitrile promoted by AlCl_3

报道了AlCl3催化邻甲氧基苯胺与丙烯腈发生Michael加成反应合成N-氰乙基-邻甲氧基苯胺、N,N-二氰乙基-邻甲氧基苯胺。结果表明,在60～64℃、10%(占邻甲氧基苯胺的摩尔百分数,以下同)无水AlCl3催化下反应12h,生成N-氰乙基-邻甲氧基苯胺,收率88%;在80～84℃、60%无水AlCl3催化下反应16h,生成N,N-二氰乙基-邻甲氧基苯胺,收率90%。用毛细管气相色谱法对合成的N-氰乙基-邻甲氧基苯胺、N,N-二氰乙基-邻甲氧基苯胺进行了含量的测定,并对其物性和结构进行了表征。

In this paper,the Michael addition of 2-metla0xyaniline to aerylonitrile promoted by AlCl3 was reported to produce 2- methoxy-N-eyanoethylaniline and 2-methoxy-N, N-dieyanoethylaniline. The yield of 2-methoxy-N-cyanoethylaniline was over 88% in the reaction catalyzed by 10（mol）% AlCl3 at 60- 64 ℃for 12 h, while the yield of 2-methoxy-N, N-dicyanoethylaniline was over 90% in the reaction catalyzed by 60（mol）% AlCl3 at 80 - 84 ℃ for 16 h. The content of 2-methoxy-N-eyano-ethylaniline and 2-methoxy-N, N-dicyanoethylaniline was analyzed by capillary gas chromatography. At the same time, the physical property and structure of the products were characterized.