中医治疗重型肝炎药物配伍规律的研究

The Compatibility Principles for Chinese Drugs Used to Treat Severe Hepatitis

目的:探索重型肝炎治疗中的遣药组方规律。方法:查阅古今文献17部和1993-2007年国内专业期刊文献328余篇,收集所载治疗重型肝炎的方剂503首,按证型分类确定树结构编写计算机统计程序。结果:表明清热解毒药、活血化瘀药、利湿化痰药在治疗重型肝炎的古今系列方剂中占主导地位。结论:结果与中医重型肝炎病因病机的理论高度吻合,反映出古今医家疾病识别系统的敏感和辨证与论治的高度统一。

Objective ： To investigate the compatibility principles for Chinese drugs used to treat severe hepatitis. Methods ： A total of 503 formulas for the treatment of severe hepatitis were identified by searching among 17 ancient or current medical works and approximately 328 articles published between 1993 and 2007 in China. A computer statistical program was constructed based on a tree structure of the formulas sorted according to syndrome types. Results ： Among the identified formulas for the treatment of severe hepatitis, drugs with the following properties were most likely to be used： heat - clearing and detoxifying, blood - activating and stasis - resolving, and dampness - draining and phlegm - resolving. Conclusions ： The findings were highly consistent with the theories regarding the etiologies and pathogeneses of severe hepatitis in traditional Chinese medicine, suggesting 1 ） a sensitivity of the systems used by ancient and current physicians for disease identification and 2） a great agreement between syndrome identification and treatment in the systems.