中药石菖蒲提取物对记忆障碍小鼠模型的改善作用研究

The Election for the Effective Fractions Extracted From Acorus Gramineus on Restoring Consciousness and Inducing Resuscitation of Model Mice

目的:明确石菖蒲开窍醒脑作用的活性物质,比较石菖蒲挥发油和去油水提物提高学习记忆作用的强度。方法:采用Morris水迷宫法、避暗法、跳台法、Y电迷宫等实验方法,观察石菖蒲提取物对化学药物所致记忆障碍模型小鼠学习记忆的影响。结果:石菖蒲挥发油和水提物均能明显提高老年小鼠学习记忆能力,改善东莨菪碱、亚硝酸钠和乙醇致记忆障碍模型小鼠的学习记忆功能。结论:石菖蒲挥发油和水提物均是该药开窍醒脑作用的物质基础,且两者作用强度无显著差别。

Objective：To select the active fractions extracted from Acorus gramineus on restoring and inducing resuscitation. To assess the effect of the total volatile oil and extracts（ distilled Oil is not included）. Methods： Experiments have been carried out with the total volatile oil and extracts（ distilled oil is not included）through different animal experiments （by electric maze method; step -down test etc） ,Results： Both of the two extract have showed functions in the promotion and improvement of the learning and memory of model mouse, such as the increase of the abihty of its learning and memory. Conclusion ：The volatile oil and extracts（ distilled oil is not included）have the good effect on restoring consciousness and inducing resuscitation and there is no great difference between them.