S-萘普生印迹聚合物药物释放性能的研究

Study of release on the moleculary imprinted polymer for S-naproxen

目的:利用药物可与分子印迹聚合物特异性结合的特性,控制药物释放。方法:以甲基丙烯酸为功能单体,二甲基丙烯酸乙二醇酯为交联剂,甲苯/异辛烷为致孔剂,在模板存在下利用本体聚合法制备分子印迹聚合物。所得的印迹聚合物与S-萘普生结合,用紫外分光光度仪测定药物的释放度。结果:S-萘普生累积释放曲线可以看出交联剂、致孔剂的用量变化会给分子印迹聚合物的外观和释药性能带来变化。结论:分子印迹聚合物对S-萘普生有一定的特异性结合,可以作为一种载体控制药物的释放。

Objective： To describe the development of molecular imprinted technology as a special polymer materials for controlling drugs release. Methods： S - naproxen was used as a template elements, methacrylate as a functional monomer, ethylene glycol methyl ester as the cross-linker, and a mixture of toluene and isooctane as porogen to prepare molecularly imprinted polymers by bulk polymerization. Drug release of the molecularly imprinted polymer was detected using UV spectrophotometry. Results： Release profiles in different PH buffer, content of porogen and the ration of functional monomer and cross-linker showed an obvious control-release effect. Conclusion： MIPs can be used as a controlled-release drug delivery system due to its specific binds to the template.