甘油三酯与中年冠状动脉粥样硬化病变关系的研究

Study on the relationship between triglyceride and severity of coronary arteriosclerosis lesion in middle age patients

目的:通过比较中年冠心病患者在甘油三酯(TG)的不同分层下行经皮冠状动脉介入治疗(PCI)术的特点,探讨TG对中年冠心病患者冠脉狭窄严重程度及病变血管范围的影响。方法:⑴对行PCI术并植入金属支架的531例中年冠心病患者(45岁≤年龄<60岁)病历进行回顾性分析。(2)按TG测定结果分为3组:①Ⅰ组:TG<1.70mmol/L,n=234。②Ⅱ组:1.70mmol/L≤TG≤2.25mmol/L,n=114。③Ⅲ组:TG≥2.26mmol/L,n=183。(3)数据处理采用SPSS11.5统计分析软件包进行。结果:⑴Ⅰ组的TC、非HDL-C及空腹血糖明显低于Ⅱ组、Ⅲ组,Ⅱ组的LDL-C明显高于Ⅰ组、Ⅲ组(P<0.05),3组间的HDL-C无差异(P=0.534)。(2)3组患者的病变血管范围、冠脉病变狭窄严重程度差异无统计学意义(P>0.05)。结论:高TG血症可能对中年冠心病患者冠脉狭窄严重程度及病变血管范围影响较小,不是其冠心病严重程度的决定性因素。

Objective： To compare the clinical characteristics in CHD middle age patients （≥45y, 〈 60y）with or without hypertriglyceridemia underwent PCI and evaluate the impact of triglyceride on severity of coronary artery stenosis and the extent. Methods; （1）531 records of middle age patients implanted metal stents were analyzed retrospectively. （2）The patients were divided into three groups according to TG results： Ⅰ group （plasma TG〈1.70mmol/L, n = 234）, Ⅱ group （plasma 1.70 mmol/L≤TG ≤2.25 mmol/L, n =114） and m group （TG ≥ 2.26 mmol/L, n = 183）. （3）All statistical analyses were performed with SPSS, version 11.5. Results： （1）TC, non-HDL-C and fasting glucose were lower in Ⅰ group than those in Ⅱ, Ⅲ group with statistical significance, there were no significant difference between the three groups in LDL-C. （2） There were no significant difference between the three groups in severity of coronary artery stenosis and regarding the extent of coronary artery. Conclusion; There were no significant difference between the three groups in severity of coronary artery stenosis and regarding the extent of coronary artery, it isn＇t the determiner on severity of CHD.