手足口病患儿免疫功能临床分析

Clinical significance of immune function in patients with hand-foot-mouth disease

目的:研究手足口病患儿外周血T淋巴细胞亚群、免疫球蛋白及补体水平变化,探讨其免疫功能改变及发病机制。方法:以临床确诊的39例手足口病患儿为研究对象,应用流式细胞仪检测CD3、CD4、CD8,计算CD4/CD8比值;用动态比浊法测定IgA、IgG、IgM,C3C及C4;并与27例正常健康儿童进行比较。结果:患儿的CD3、CD4、CD8升高,CD4/CD8比值降低;血清IgM、IgG显著高于健康儿童,IgA水平降低。血清C3C及C4水平无明显变化。结论:手足口病患儿出现细胞免疫和体液免疫功能紊乱。

Objective： To evaluate the clinical significance of the lever of T-cell subpopulations, immunoglobulin and complement in patients with hand-foot- mouth disease. Methods：39 patients with hand-foot- mouth disease and 27 control normal subjects were included in this study. The change Of T-cell subsets was analyzed by flow cytometr,immunoglobulin and complement were analyzed by Kinetic Turbidimetric Assay. Results： Compared with the control normal subjects, the levels of CD3, CD4, CD8 were increased ,and the ratio of CD4 to CD8 were reduced （P〈0.05） in patients with hand-foot- mouth disease. The level of IgM and IgG were higher than those in control nomal subjects, but the level of IgA was lower （P〈0.05）. The level of C3C and C4 in the two group were not obviouly different （P〉0.05）. Conclusion： The immune function are disordered in patients with hand-foot- mouth disease.