摘要
目的:观察洛赛克联合西沙比利治疗反流性食管炎的疗效。方法:回顾分析2007年1月～2008年12月收治的90例反流性食管炎患者,随机分为治疗组和对照组各45例。治疗组用洛赛克20mg,2次/日;加用西沙比利10mg,3次/日,饭前15～30分钟口服。对照组单独服用与治疗组同厂家、同批号的西沙比利10mg/次,每日3次,饭前15～30分钟口服。疗程4周。结果:治疗4周后两组临床症状均有所缓解,治疗组总有效率明显高于对照组(P<0.05)。治疗组患者胃镜下食管炎愈合有效率与对照组差异有统计学意义(P<0.05)。结论:洛赛克与西沙比利联合使用治疗反流性食管炎疗效优于单独使用西沙比利。
Purpose： Observe curative effect of Losee and Cisapride in reflux esophagitis. Method：Review and analyze 90 cases of reflux esophagitis treated in our hospital from January 2007 to December 2008, and randomly divide them into treatment group and control group with 45 cases in each group. Use 20mg Losec for the treatment group at 2 times/d and 10mg Cisapride at 3 times/d. Take them orally before meals; 15 -30 mi- nautes before meals, the control group only independently take the Cisapride orally at 3 times/d and 10mg/times. The treatment lasts four weeks. Result ： after 4 - week treat- ment, clinical symptoms of the two groups are relieved. The total efficiency of the treat- ment group is evidently higher than the con- trol group （ P 〈 0. 05 ）. There is statisti-cahneaning in difference of the esophagitis healing effectiveness ratio under the gastro- scope between patients of the treatment group and the control grouip （ P 〈 0. 05 ）. Conchlsion： Curative effect of l,osee and Cisapride in retlux esophagitis exceeds that of Cisapride.
