平阳霉素碘油乳剂超选择动脉栓塞治疗肝血管瘤的观察

Observation of superselectively hepatic artery embolization treatment with pingyangmycin lipiodol emulsion for patients with liver cavernous hemangioma

为了探讨平阳霉素碘油乳剂超选择栓塞化疗治疗肝血管瘤(HCH)的临床疗效和治疗体会,对23例HCH患者采用平阳霉素碘油乳剂超选择性动脉插管动脉栓塞治疗,观察治疗前和治疗后6、12个月时患者临床症状、肿瘤大小的变化以及出现的并发症。23例患者在术后6和12个月复查CT,见瘤体血供消失,其内碘油沉积良好,并出现瘤体缩小、碘油聚积征象。术前血管瘤直径为(8.1±2.2)cm,术后6个月血管瘤直径为(5.4±1.3)cm,术后12个月血管瘤直径为(3.4±1.2)cm。治疗前有临床症状者治疗后缓解或消失,术后均未出现胆囊坏死、胆管狭窄和肝坏死等严重并发症发生。初步研究结果提示,超选择性肝动脉插管平阳霉素碘油乳剂栓塞治疗巨大HCH是一种疗效肯定、相对安全较为理想的治疗方法。

The objective of this study was to evaluate the safety and efficacy of superselectively hepatic artery embolization treatment with pingyangmycin lipiodol emulsion for patients with liver cavernous hemangioma. Twenty three patients with hepatic cavernous hemangioma underwent the superselectively hepatic artery embolization with pingyangmycin lipiodol emulsion. The changes of clinical symptoms, tumour diameters and complications were observed before the treatment and 6 and 12 months after the treatment. CT scans showed that the supplication of blood disappeared, and tumor diameter reduced in all the patients 6 and 12 months after the treatment. The lipiodol deposited well in the tumoral lesions of the most patients. The mean tumor diameter was （8. 1±2.2） cm before the treatment and （5.4±1.3） cm 6 months after the treatment, and （3.4±1.2） cm 12 months after the treatment. The clinical symptoms alleviated or disappeared in all the patients. No severe complications such as gallbladder injury, bile stuct strick and liver function failure developed during and after the therapy. In conclusion, the superselectively hepatic artery embolization treatment with pingyangmycin lipiodol emulsion is an effectve and safe method for patients with hepatic cavernous hemangioma.