阿魏酸钠对糖尿病肾病的保护作用及机制

Protective Effects of Sodium Ferulate on Diabetic Nephropaphy and its Mechanism

目的:观察阿魏酸钠对糖尿病肾病伴高脂血症患者血脂、内皮素、一氧化氮、24h尿蛋白的影响。方法:将60例糖尿病肾病伴高脂血症患者随机分为治疗组(30例)和对照组(30例),两组基础治疗相同,治疗组在对照组基础治疗上加用阿魏酸钠,治疗4周后观察两组患者血脂、内皮素、一氧化氮、24h尿蛋白及临床症状的变化。结果:与对照组比较,治疗组在降低总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、内皮素(endothelin,ET)、24h尿蛋白和升高一氧化氮(nitric oxide,NO)方面疗效更为显著,两组升高高密度脂蛋白胆固醇(HDL-C)的疗效相似。结论:阿魏酸钠可有效调节糖尿病肾病伴高脂血症患者血脂水平,改善内皮功能,降低尿蛋白,对糖尿病肾病有保护作用。

Objective： To observe the effects of Sodium ferulate on blood lipid, endothelin, proteinuria and nitric oxide in patients with Diabetic nephropaphy（DN）accompanied with hyperlipoproteinemia. Methods： Sixty patients with DN and hyperlipoproteinemia were divided into experimental group （ n = 30） and control group（ n = 30）randomly, and basal treatment was given to both groups. The experi - mental group was treated with Sodium ferulate. Changes of blood lipid, plasma ehdothelin, nitric oxide, proteinuria and clinical symptom were observed after administration of the medicine for 4 weeks. Results：As compared with the control group, after patients had been treated with Sodium ferulate for 4 weeks, significant improvement was shown in lipid abnormality. The levels of total cholesterol （TC）, Triglyceride （TG）, low density lipoprotein cholesterol （LDL - C）, endothelin（ET）, proteinuria were lowered and nitric oxide（NO） increased obviously. The effect of both remedies in elevating HDL- C was similar. Conclusion： Sodium ferulate has definite regulatory effect on the blood lipids and lipoproteins in patients with DN and hyperlipoproteinemia, decrease proteinuria and ean improve endothelial function, and protect kindey.