摘要
目的：观察端粒酶和视网膜母细胞瘤基因蛋白（pRb）在结直肠癌中的表达，并探讨它们之间的相关性。方法：应用免疫组化法检测48例结直肠癌组织中端粒酶和pRb的表达，并用统计学方法分析表达结果与结直肠癌临床病理因素间的关系。结果：结直肠癌中端粒酶和pRb的阳性表达率分别为87．5％和56．3％，且与结直肠癌区域淋巴结转移和临床分期关系密切（P〈0．05），端粒酶表达还与组织病理学分级密切相关（P〈0．05）。结论：检测结直肠癌组织中端粒酶和pRb的表达有助于结直肠癌患者的预后评估，结直肠癌组织中端粒酶与pRb表达呈显著负相关关系，两者可能从不同方面共同促进结直肠癌的发生。
Objective：To investigate the expression of telomerase and pRb in colorectal cancer and explore the correlation between them. Methods：The immunohistochemistry method was used to detect the expression of telomerase and pRb in 48 specimens of colorectal cancer. The findings was analyzed by a statistical method, and compared with the clinicopathologic factors of colorectal carcinoma, and then to explore the relationship between them. Results：The positive expression rates of telomerase and pRb in colorectal cancer were 87.5% and 56.3%, respectively, which closely related to the lymph node metastasis and clinical stages of colorectal cancer（P 〈 0.05）, furthermore, the expressive level of telomerase was positively correlated with the histopathological grading. Conclusions：Detecting the expression of telomerase and pRb protein may be helpful to evaluate the prognosis of colorectal cancer. The expression of telomerase was negatively correlated with the expression of pRb （ P 〈 0.05 ） protein. It suggests that telomerase and pRb protein may promote the carcinogenesis from various aspects.
出处
《解剖与临床》
2009年第5期316-319,共4页
Anatomy and Clinics
