摘要
超声在液体中作为一个振荡源诱发空化,产生的空泡因其独特的性质可作为基因输送和药物靶向传输的载体。本文就空化机制、声致穿孔控制和超声造影剂的影响三个方面展开论述,探讨了上述问题的研究现状与面临的挑战,旨在为超声空化空泡作为载体的临床应用研究提供文献支持。
Ultrasound, serveing as an oscillating source, can induce cavitation in liquids; and the bubble produced in this process is a very promising kind of vector for gene delivery and drug target release, owing to its unique properties. This article involves the cavitation mechanism, the control over sonoporation, and the influence of ultrasound contrast agent. The status quo of research and the challenges encountered are discussed. This overview is devoted to providing a theoretical basis for clinical use of cavitating bubble vector.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2009年第5期1129-1132,共4页
Journal of Biomedical Engineering
基金
国家自然科学基金资助项目(50746022)
北京自然科学基金资助项目(3073020)
关键词
超声空化空泡
载体
空化机制
声致穿孔超声造影剂
Ultrasonic eavitating bubble Vector Cavitation mechanism Sonoporation Ultrasound contrast agent