5-羟色胺／褪黑素能系统对MC和AMMC的作用机制

Pathogenesis of Serotoninergic/melatoninergic Systems Signalling Pathway on Melanocytes and Amelanotic Melanocytes of Hair Outer Root Sheath

白癜风患者皮损在色素恢复过程中,白斑边缘正常表皮基底层黑素细胞和毛囊外毛根鞘无活性黑素细胞(AMMC)是白癜风患者皮损色素恢复的两个途径。AMMC可被某些特定因子激活、增殖和游走,并产生黑素,可能是黑素干细胞。5-羟色胺/褪黑素能系统(5-HTs/MTs)对黑素细胞(MC)和AMMC的增殖和凋亡产生作用;5-羟色胺(5-HT)抑制黑素生成,黑素细胞内生成褪黑(激)素(MT)可能是黑素的内在调节剂,因而探讨5-HTs/MTs信号转导途径对AMMC的作用机制,可进一步揭示白癜风的发病机理,对开发新的5-HT类药物及临床治疗提供科学依据,具有重要的理论和应用价值。

There are two biological pathways to synthesize melanonin in vitiligo which involved in amelanotic melanocyte in outer root sheath of hair follicles （ AMMC ） and melanocyte （ MC ） in stratum basale of normal skin around lesions. AMMC has been experimentally implicated in some features of melanocyte stem-cell or it＇s functions such as proliferation, synthesizing melanonin, after activated by some specific factors. The serotoninergic and melatoninergic systems induced proliferation and apoptosis of some skin cells. Serotonin（5-HT） inhibited the process of synthesizing melanonin. Melatoinin（MT） （ synthesized locally ） regulated on the process of synthesizing melanonin. It is anticipated that the discovery of biological pathways of vitiligo pathogenesis will provide novel therapeutic and prophylactic targets for future approaches to the treatment and prevention of vitiligo.