中国人弥漫性泛细支气管炎和冷凝集试验的探讨

Correlation between cold hemoagglutinin and diffuse panbronchiolitis in Chinese

目的探讨冷凝集试验(CHA)在中国人弥漫性泛细支气管炎(DPB)的价值,为临床诊断提供线索。方法1996年12月～2008年7月在北京协和医院诊断为DPB的患者18例和国内自1996年首例DPB报道以来以病例报告形式报道的病例60例,对其进行临床、CHA试验综合分析。结果北京协和医院诊断为DPB的18例患者仅有1例CHA阳性。国内60例DPB病例,48例患者描述了CHA结果,总阳性率54.1%。CHA阳性率与治疗药物的应用、人群等有一定相关性。结论CHA试验在中国DPB患者中的低阳性率,提示这一指标可能不适合于中国DPB的诊断标准。

Objective To identify a potential correlation between cold hemoagglutinin （CHA） and diffuse panbron-chiolitis（DPB） in Chinese patients. Methods Eighteen patients diagnosed as DPB from December 1996 to July 2008 in Peking Union Medical College Hospital and 60 cases of DPB reported in mainland of China from 1996 to 2008 were enrolled in the study. Results Of 18 patients diagnosed as DPB in Peking Union Medical College Hos- pital, only one patient showed a titer of CHA≥1 ： 64. Of 60 cases in China's Mainland, 48 cases were CHA positive. CHA was positive in 54.1% all cases. There may be some correlation between positive rate of CHA and medication as well as population. Conclusion Low positive rate of CHA in Chinese subjects, which is different from that of Japanese DPB patients, suggests that CHA may not be applied as a diagnostic criteria for Chinese patients.