限制性输液对失血性休克大鼠血流动力学的影响

The effect of limited fluid resuscitation on hemodynamics in rats with hemorrhagic shock

目的探讨限制性输液对失血性休克大鼠血流动力学的影响。方法制作大鼠失血性休克模型,采取限制性输液和大量输液两种不同输液方法复苏大鼠失血性休克,对比各组不同时间点的血流动力学变化,记录出血量、输液量并计算生存率。结果休克模型120 min后,与大量输液组比较,限制性输液组的呼吸、心率降低,有统计学意义,平均动脉压和中心静脉压明显升高(P<0.05);休克急救期,限制性输液组失血量少于大量输液组(P<0.05),输液量明显低于大量输液组(P<0.05);休克后24 h和72 h生存率比较,限制性输液组高于大量输液组(P<0.05)。结论限制性输液能明显改善失血性休克大鼠的血流动力学,减少失血量以及输液量,提高生存率,是复苏失血性休克的理想方法。

Objective To investigate the effect of limited fluid resuscitation on hemodynamics in rats with hemorrhagic shock. Methods The model of hemorrhagic shock was established in rats. Hemorrhagic shock was resuscitated by two different transfusion means： limited fluid transfusion and traditional transfusion. The hemodynamic changes at various time points, the volume of blood loss, blood/fluid transfusion at various period of shock and survival rate were compared between the two groups. Results At 120 min after the establishment of shock model, respiration and heart rate decreased while the mean arterial pressure （MAP） and the central venous pressure （CVP） were significantly increased in the limited fluid transfusion group than those in traditional resuscitation group （ P 〈 0. 05 ）. During the early treatment of shock, the volume of blood loss in limited fluid resuscitation group was significantly lower than that of traditional resuscitation group （ P 〈 0. 05 ）. The volume of blood/fluid transfusion was even lower during this period （ P 〈 0. 05 ） in limited transfiasion group. The survival rates at 24 h and 72 h after shock in traditional resuscitation group were lower than those in limited fluid resuscitation group （ P 〈 0. 05 ）. Conclusion Limited fluid resuscitation can significantly improve the hemodynamics of hemorrhagic shock rats, reduce the volume of blood loss and blood/fluid transfusion, and increase the survival. It is an ideal resuscitation for hemorrhagic shock.