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原发性痛风患者肾脏排泄尿酸减少分析 被引量:2

Renal excretion of uric acid is reduced in patients with primary gout
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摘要 目的探讨原发性痛风患者是否存在肾脏排泄尿酸减少。方法对56例原发性痛风患者及43例正常对照人群的肾脏排泄尿酸情况进行了研究,观察指标包括肾功能、尿肌酐(Ucr)、尿尿酸(Uur)、24 h尿尿酸总量(24 h Uur)、肌酐清除率(Ccr)、尿酸清除率(Cur)、尿酸清除分数(FRUAC)、单位肾小球滤过率尿酸排出(Eu-rGF)、肾小球尿酸负荷(Flur)及尿尿酸与尿肌酐比值(Uur/Ucr)等。其中尿酸的测定采用尿酸酶法,肌酐的测定采用三硝基苦味酸法。结果原发性痛风患者的血尿酸、24 h Uur及Flur均明显高于正常对照人群(P<0.05),而Cur及FRUAC则低于正常对照人群(P<0.05)。结论中国原发性痛风患者存在肾脏排泄尿酸能力的降低。 Objective To study whether reduced excretion of uric acid is present in Chinese patients with primary gout. Methods Serum samples and 24 - hour urine samples obtained from 56 primary gout patients and 43 normal age - matched subjects were measured for renal function, 24 -hour urinary uric acid excretion (24 h Uur), uric acid clearance ( Cur), creatinine clearance (Ccr) , fractional excretion of uric acid (FRUAC) , excretion of uric acid per volume of glomerular filtration (EurGF), urinary uric acid to ereatinine ratio (Uur/Ucr), and glomerular uric acid filtered load (Flur). Results Patients with primary gout showed hyperuricemia, high 24h Uur and Flur level, but showed lower uric acid clearance and fractional excretion of uric acid ( P 〈 0. 05 ). Conclusion Renal excretion of uric acid is reduced in Chinese patients with primary gout.
出处 《广东医学》 CAS CSCD 北大核心 2009年第10期1492-1494,共3页 Guangdong Medical Journal
基金 广东省医学科研基金资助项目(编号:B2007160) 广东省深圳市医学重点学科建设基金资助项目(编号:2005C10)
关键词 痛风 原发性 尿酸 高尿酸血症 gout primary uric acid hyperuricemia
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