1VIGERS G P, DRIPPS D J, EDWARDS C R, et al. X - ray crystal structure of a small antagonist peptide bound to interleukin - 1 receptor type 1 [J]. J Biol Chem, 2000, 275 (47) : 36 927 - 36 933.
2AURON P E, WEBB A C, ROSENWASSER L J, et al. Nueleotide sequence of human monocyte interleukin 1 precursor cDNA Proc Natl Acad Sci USA, 1984, 81 : 7 907 -7 911.
3AURON P E, WEBB A C, ROSENWASSER L J, et al. Nueleotide sequence of human monocyte interleukin 1 precursor cDNA Proc Natl Acad Sci USA[J]. J Immunol, 2007, 178(9): 5 413 -5 417.
4CHAU T L, GIOIA R, GATOT J S, et al. Are the IKKs and IKK -related kinases TBK1 and IKK - epsilon similarly activated? [J]. Trends Biochem Sci, 2008, 33(4) : 171 -180.
5O' NEILL L A J. The interleukin - 1 receptor/Toll - like receptor superfamily:10 years of progress[J]. 2008 : 226,10 - 18.
6BUTLER M P, HANLY J A, MOYNAGH P N. Kinase -active interleukin - 1 receptor - associated kinases promote polyubiquiti- nation and degradation of the Pellino family: direct evidence for PELLINO proteins being ubiquitin -protein isopeptide ligases[ J ]. J Biol Chem, 2007, 282(41 ) : 29 729 -29 737.
7ORDUREAU A, SMITH H, WINDHEIM M, et al. The IRAK - catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63 - linked polyubiquitination of IRAKI [ J ]. Biochem J, 2008, 409(1) :43 -52.
8DINARELLO C A. Immunological and inflammatory functions of the interleukin- 1 family [ J ], Annu Rev Immunol, 2009, 27 (2) : 519-550.
9BASU A, KRADY J K, O' MALLEY M, et al. The type 1 interleukin - 1 receptor is essential for the efficient activation of microglia and the induction of multiple proinflammatory mediators in response to brain injury[J]. J Neurosci, 2002, 22(14) : 6 071 - 6 082.
10BOUTIN H, KIMBER I, ROTHWELL N J, et al. The expanding interleukin - 1 family and its receptors: do alternative IL - 1 receptor/signaling pathways exist in the brain [J]. Mol Neurobiol, 2003, 27 (3) : 239 - 248.
二级参考文献6
1STRAND V, KAVANAUGH A F. The role of interleukin - 1 in bone resorption in rheumatoid arthritis[J].Rheumatology ( Oxford), 2004, 43(Suppl 3) : Ⅲ10 - Ⅲ16.
2HUR W, CHO M L, YOON S K, et al. Adenoviral delivery of IL-1 receptor antagonist abrogates disease activity during the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice[J]. Immunol Lett, 2006, 106(2):154-162.
3MUKHERJEE P, YANG S Y, WU B, et al. Tumour necrosis factor receptor gene therapy affects cellular immune responses in collagen induced arthritis in mice[J]. Ann Rheum Dis, 2005, 64: 1550-1556.
4NEUMANN E, JUDEX M, KULLMANN F, et al. Inhibition of cartilage destruction by double gene transfer of IL-1Ra and IL-10 involves the aetivin pathway[J].Gene Ther, 2002, 9 ( 22 ) : 1508-1519.
5KIM J M, JEONC J G, HO S H. Protection against collagen-induced arthritis by intramuscular gene therapy with an expression plasmid for the interleukin-1 receptor antagonist[J].Gene Therapy, 2003, 10:1543 -1550.
6EVANS C H, ROBBINS P D, GHIVIZZANI S C, et al. Gene transfer to human joints: Progress toward a gene therapy of arthritis[J].PNAS. 2005. 102:8698-8703.
3Dinan TG,Quigley EM,Ahmed SM,et al.Hypothalamic-pituitary gut axis dysregulation in irritable bowel syndrome:plasma cytokines as a potential biomarker[J].Gastroenterology,2006,130 (2):304-311.
4Dantzer R.Cytokine-indueed sickness behavior:mechanisms and implications[J].Ann NY A cad Sci,2001,933(6):222-234.
5Maes M.Major depression and activation of the inflammatory response system[M].In:Dantzer R,Wollman EE,Vitkovic L,et al.Cvtokines,Stress and Depression.New York:Kluwer Academic/Plenum Publishers,1999:25-46.
6Maes M,Meltzer H,Bosmans E,et al.Increased plasma concentrations of interleukin-6,soluble interleukin-6 receptor,soluble interleukin-2 receptor and transferrin receptor in major depression[J].J Affect Disord,1995,34(4):301-309.
7Schlatter J,Ortuno F,Cervera-Enguix S.Differences in interleukin patterns between dysthymia and major depression[J].Eur Psychiatry,2001,16(5):317-319.
8Schwarz NT,Kalff JC,Turler A,et al.Selective ieiunal an ipulationcauses postoperative panenteric inflammation and dysmotility[J].Gastroenterology,2004,126(7):159-169.
9Dinan TG,Quigley EM,Ahmed SM,et al.Hypothalamic pituitary gut axis dysregulation in irritable bowel syndrome:plasma cytokines as a potential biomarker[J] ? Gastroenterology,2006,130 (2):304-311.
10Ohama T,Hori M,Sato K,et al.Chronic treatment with interleukin1 beta attenuates contractions by decreasing the activities of CPI-17and MYPT-1 in intestinal smooth muscle[J].J Biol Chem,2003,278 (49):48794-804.
