长期服用保列治对前列腺增生患者静态尿道压力影响的研究

Study of influence of long-term treatment of finasteride on quiet state urethral pressure in patients with benign prostatic hyperplasia

目的:探讨长期服用保列治对前列腺增生患者尿道压的影响。方法:前列腺增生患者48例分成2组,各24例,实验组给予口服保列治+特拉唑嗪治疗,对照组给予安慰剂+特拉唑嗪治疗,治疗时间为3年,治疗前、服用保列治治疗1年、3年后行超声及尿流动力学检查,比较治疗前后患者前列腺体积、功能性尿道长度、最大尿道压、最大尿道闭合压变化情况。结果:在服用药物治疗3年后,实验组患者前列腺体积较对照组明显缩小(P<0.05),实验组患者最大尿道压和最大尿道闭合压力较对照组也明显降低(P<0.05)。结论:长期服用保列治可以缩小前列腺体积,降低增生前列腺组织对尿道的静态压力,从而改善尿路梗阻症状。

Objective： To explore the long - term efficacy of finasteride on quiet state urethral pressure in patients with benign prostatic hyperplasia（BPH）. Methods： Forty - eight patients with BPH in our hospital were randomly assigned to the following groups（ n = 24） ： （ 1 ） Finastefide group ： Patients were treated with finasteride plus terazosin daily for 3 years. （ 2 ） Control group ： Patients were treated with placebo plus terazosin daily for 3 years. Before and after the treatment for 1,3 years, the prostate volume, functional urethral length, maximal urethral pressure and maximal urethral closure pressure were evaluated. Results： After treatment with finastcride for 3 years, the prostate volume, maximal urethral pressure and maximal urethral closure pressure of patients decreased significantly compared with control group （P 〈 0.05 ）. Conclusion：Long - term administration of finasteride in patients with BPH may reduce prostate volume and quiet state urethral pressure. Therefore, it can improve urinary obstruction symptom.