雄激素与老年男性下肢动脉硬化闭塞症的相关性研究

Relationship between androgen and arteriosclerosis obliterans in old males

目的探讨老年男性下肢动脉硬化闭塞症患者的雄激素水平变化。方法选择男性下肢动脉硬化闭塞症患者38例和男性健康者38例,检测并比较血清总睾酮(TT)和游离睾酮(FT))水平。结果老年男性下肢动脉硬化闭塞症患者的总睾酮水平无显著下降,而游离睾酮水平明显下降。结论游离睾酮水平下降可能与老年男性下肢动脉硬化闭塞症有关,雄激素补充治疗可能在老年男性下肢动脉硬化闭塞症患者的药物治疗中起到重要作用。

Objective To investigate relation between androgen and arteriosclerosis obliterans in old males. Meth- ods A case control study was performed in 38 patients with arteriosclerosis obliterans（ASO） of lower extremity in old males and 38 healthy men. Total testosterone CTT） and free testosterone （FT） were measured. Results TT of patients with ASO had no significant decrease, but FT was decreased significantly. Conclusion Descended FT was likely to relate with ASO in old males. It will likely play an important role to supplementary treatment of androgen for ASO in old males.