高原地区不同民族萎缩性胃炎患者血清胃蛋白酶原水平的变化

The Changes of Serum Level of Pepsinogen in Patients with Atrophic Gastritis among Different Race at High Altitude

目的:探讨高原地区不同民族慢性萎缩性胃炎(CAG)与血清胃蛋白酶原(PG)的关系,以及Hp感染对其的影响。方法:利用日立7170S型全自动生化分析仪,采用速率法测定经内镜检查和病理学确诊的慢性萎缩性胃炎376例(汉族143例,回族110例,藏族123例)患者的血清PG水平,并与39例胃黏膜基本正常(NOR)者作对比分析,同时观察Hp感染对不同民族CAG血清PG水平的影响。结果:不同民族CAG患者和正常者Hp检出率均高,平均达80.79%,各民族之间无统计学差别(P>0.05);Hp感染对不同民族CAG患者和正常者血清PG水平和PGⅠ/PGⅡ值均无显著影响(均P>0.05);汉族、回族和藏族CAG患者血清PGⅠ水平和PGⅠ/PGⅡ值明显低于正常者(P<0.01),而回族CAG患者血清PGⅠ水平和PGⅠ/PGⅡ值又明显低于汉族和藏族(P<0.05),汉族和藏族之间无统计学差别(均P>0.05);血清PGⅡ水平仅回族明显低于正常者(P<0.01),而汉族、回族和藏族之间均无统计学差别(均P>0.05);不同民族CAG患者男女之间血清PGⅠ、PGⅡ水平和PGⅠ/PGⅡ值均无显著性差别(均P>0.05)。结论:Hp感染对高原地区不同民族CAG患者血清PG水平无影响。不同民族CAG患者中血清PG水平存在差别,表现为回族明显低于汉族和藏族,而同民族不同性别之间无差别。

Objective： To study the correlation between serum pepsinogen （PG） level and chronic atrophic gastritis （CAG） in different race patients in the plateau area, and effect of infection of Hp. Methods： 376 patients with chronic atrophic gastritis included 143 Han population.110 Hui population and 123 Tibetan were recruited in this study. The chronic atrophic gastritis was considered by endoscope doctor and pathologist. And 39 subjects who had normal gastric mucosa served as the control. Level of PG was measured by Velocity method using Rill 7170S Full--automatic bio--chemical analysis instrument, and whether the results associated with Hp to be observed. Results：The detective rate of Hp was meanly 80. 79% in the CAG group and control group, but no statistical difference in level of PG and PGⅠ/PGⅡamong the three races （P〉0.05）. As compared with the control, serum level of PGI and PGⅠ/PGⅡ were significantly lower in CAG group of three races （P〈0. 01）, as well lower in CAG group of Hui population than in Han population and Tibetan （P〈0. 01）, serum level of PGⅡ was lower in Hui population only （P〈0. 01）. No sex difference on PGⅠ, PGⅡ level and PGⅠ/PGⅡ in CAG group in three races. Conclusions.There was no effect of Hp infection on serum level of PG in CAG patient in any race. There was a lower serum level of PG in CAG patient in Hui population than that in Han and Tibetan. No sex difference on PGⅠ, PGⅡ level and PGⅠ/PGⅡ in CAG patients in any race.