补骨脂注射液联合窄谱中波紫外线治疗白癜风的疗效及对外周血T淋巴细胞亚群的影响

Observation of therapeutic effect of psorales plus narrow-band ultraviolet B and the impact on T-lymphocyte subpopulation in vitiligo patients

目的观察采用补骨脂注射液联合窄谱中波紫外线治疗白癜风的疗效及对外周血T淋巴细胞亚群的影响。方法32例自癜风患者按抽签法随机分为治疗组20例和对照组12例，治疗组补骨脂注射液2ml肌内注射，隔日1次；1h后按皮损面积给予局部或全身窄谱中波紫外线照射。对照组按常规给予白蚀丸2．5g,3次／d，维乐生2片，3次／d，外用15％补骨脂酊，2次／d。疗程均为3个月。比较2组患者治疗前后T淋巴细胞亚群、自然杀伤（NK）细胞变化。结果治疗组总有效率90％，对照组为75％（P〈0．05），治疗后治疗组CD3、CD4及CD4／CD8分别为：68．7±4．0、38．4±3．1、1．7±0．6，与治疗前（62．1±3．1、34．3±2．9、1．2±0．7）比较均升高，与对照组治疗后（63．9±3．7、35．4±2．9、1．4±0．5）比较，差异有统计学意义（P〈0．05）。结论白癜风患者存在细胞免疫功能异常，采用补骨脂注射液联合窄谱中波紫外线综合治疗能提高疗效及细胞免疫功能。

Objective To observe the therapeutic efect of psorales plus narrow-band ultraviolet B （NB- UVB） on T-lymphocyte subpopulation in Vitiligo patients. Methods Thirty-two vitiligo patients were divided into treatment group（20 cases） and control group （12 cases）. The levels of T-lymphocyte subpopulation and NK cell in the peripheral blood of all patients were determined with flow cytometry. Results Effective treatment rates in treatment group and controled group were 90 % and 75% （P 〈0.05）. After treatment, CD3, CD4 and CD4/CD8 increased in integrated treatment group （ P 〈 0. 05 ）, but no significant change in control group was observed. Conclusion Cellular immunity is impaired in vitiligo patients. Psorales plus NB-UVB can increase the cure rate and enhance cellular immunity.