氨溴索注射液支气管灌洗预防新生儿胎粪吸入综合征的初步疗效

Ambroxol bronchoalveolar lavage in prevention from neonatal meconium aspiration syndrome

目的探讨氨溴索注射液支气管灌洗预防新生儿胎粪吸入综合征(MAS)的疗效。方法选择胎粪羊水Ⅲ度污染的新生儿39例为研究对象。随机分为对照组20例与治疗组19例。对照组:采用生理盐水在喉镜直视下气管插管行支气管灌洗治疗;治疗组:采用稀释的氨溴索注射液在喉镜直视下气管插管行支气管灌洗治疗。观察两组病人在灌洗后的临床症状改善情况,呼吸频率、经皮氧饱和度和胸X线片等指标综合分析后,对两组患儿的MAS发生率进行比较。结果治疗组患儿的MAS发生率小于对照组(P<0.05),临床未见不良反应发生。结论氨溴索注射液支气管灌洗能减少新生儿MAS的发生率。

Objective To assess the effectiveness of Ambroxol injection fluid bronchoalveolar lavage in prevention from neonatal meconium aspiration syndrome （MAS）. Methods 39 infants with Ⅲ degree pollution by meconium and amniotic fluid were enrolled in this study. They were allocated to control group （ n = 20） and therapeutic group （ n = 19）. Control group treatment： endotracheal intubation was performed under laryngoscope and then normal saline was used for bronchoalveolar lavage. Therapeutic group： endotracheal intubation was performed under laryngoscope and then diluted Ambroxol injection fluid was used for bronchoalveolar lavage. Observed clinical improvement, respiration rate, SpO2 and X-ray presentation in both groups. Compared MAS incidence between the two groups. Results In therapeutic group the incidence of MAS was lower than that in control group （ P 〈0.05）. No side effect occurred. Conclusion Ambroxol lavage can reduce the incidence of neonatal MAS.