CD44、CD24、MMP9在涎腺腺样囊性癌的表达及意义

Expression and significance of CD44、CD24、MMP9 in adenoid cystic carcinoma cell line

目的探讨CD44、CD24、MMP9在腺样囊性癌肺高转移细胞株(ACC-M)中的表达,进一步揭示涎腺腺样囊性癌的生物学特性。方法免疫组化SP法检测CD44、CD24、MMP9在ACC-M中的表达情况。结果CD44阳性表达率为93%±3.03,CD24阳性表达率为27%±3.14,MMP9阳性表达率为89%±3.67。结论CD44、CD24和MMP9的表达与ACC-M的生物学特性有关。

Objective To investigate the expression and significance of CD44, CD24, and MMP9 in adenoid cystic carcinoma cell line （ACC-M） so as to disclose further biological characteristics of ACC-M. Methods The expression of CD24, CD44 and MMP9 are detected and analyzed in ACC-M tumor ceils by immunohistochemistry SP method. Results The expression positive rate of CIN4, CD24, and MMP9 in ACC-M were 93%±3.03, 27±3. 14 and 89%±3.67 respectively by using the immunohistochemical assay. Conclusion The high expression of CD44 and MMP9 is closely related to the high transfer of biological characteristics of ACC-M. The reduced expression of CD24 is closely related to tumor growth, invasion and metastasis.