摘要
【目的】研究O/W型药用微乳形成的基本规律及评价方法,为药用微乳的研究和应用提供一定的实验依据。【方法】通过滴定法绘制拟三元相图,考察不同表面活性剂和助表面活性剂对O/W型微乳形成的影响。【结果】在相同油相的情况下,不同表面活性剂和助表面活性剂的不同结构和性质、表面活性剂和助表面活性剂的质量比(Km)、温度的变化对微乳的形成均有影响。【结论】恰当的油相和适配的表面活性剂和助表面活性剂的合理搭配,可以使微乳体系中表面活性剂的用量降低至7.5%,而且一般微乳形成的区域大小与表面活性剂和助表面活性剂的总量成正比,与油的用量成反比。用三元相图作为选择最佳微乳组方需要结合微乳的稳定性考察来确定微乳的最佳形成条件。
Objective The basic formation rules and evaluation of the pharmaceutical microemulsions were studied in order to provide some experimental information to studying and application of pharmaceutical microemulsions.Method The titrimetric method for drawing pseudo-ternary phase diagrams was used to inspect the formation influence caused by different surfactants and CO-surfactant on the O/W microemulsions.Result In the same oil phase situation,the formation of microemulsions would be influenced by the structure and nature of surfactant and CO-surfactant, the quality ratio （Km） of surfactant and CO-surfactan as well as the temperature. [Conclusion] Appropriate oil phase and suitable matches of the surfactant and CO-surfactant can reduce the drawing pseudo-temary phase diagrams to determine the most excellent formation condition of pharmaceutical microemulsions, the stability of microemulsions needs to be unified.
出处
《中国农业科学》
CAS
CSCD
北大核心
2009年第9期3328-3333,共6页
Scientia Agricultura Sinica
基金
国家高技术研究发展计划(“863”计划)重大课题(2006AA10A203)
中央级公益性科研院所基本科研业务费专项资金项目(BRF070405)
关键词
微乳
助表面活性剂
非离子型表面活性剂
拟三元相图
pharmaceutical microemulsions
CO-surfactant
non-ionic surfactant
pseudo-ternary phase diagram
