期刊文献+

胺碘酮联合阿托伐他汀治疗阵发性心房颤动临床观察

下载PDF
导出
摘要 目的探讨胺碘酮联合阿托伐他汀治疗阵发性心房颤动的安全性及有效性。方法选择58例发作频繁的阵发性房颤患者,随机分成治疗组(胺碘酮联合阿托伐他汀),对照组(单用胺碘酮),随访时间1年。结果治疗组总有效率72.4%(21/29),对照组总有效率48.1%(13/27),两组比较差异有统计学意义(P〈0.05)。治疗组的低密度脂蛋白胆固醇(LDL—C)水平显著下降,与对照组比较差异有统计学意义(P〈0.05),两组的安全性相当。结论和单纯应用胺碘酮相比,胺碘酮联合阿托伐他汀能显著减少阵发性房颤的复发,且未增加严重不良反应。
出处 《浙江临床医学》 2009年第9期934-935,共2页 Zhejiang Clinical Medical Journal
  • 相关文献

参考文献6

  • 1Roy D, Talajic M, Dorian P, et al. A miuodarone to Prevent Recarrence of Atrial Fibrillation. N Eng J Med ,2000,34 (2) :913 - 920.
  • 2Patel AA,W hite CM,Shah SA,et al The relationship between statin use and atrial fibrillation. CurrM ed Res O pin ,2007,23 (5) :1177 - 1185.
  • 3A viles RJ,M artin DO,Appem on HC, et al. Inflammation as a risk flactor for atrial fibrillation. Circulation,2003,108 (4) :3006 - 3010.
  • 4Lin PH, Lee SH, Su CP, et al. Oxidative damage to mitoehondrial DNA in atrial muscle of patients with atrial fibrillation. Free R adic B iolM ed,2003,35 (2) :1310 - 1318.
  • 5K othe H, Dalhoff K, Rupp J,et al H ydroxym ethylg lutary 1 coenzyme A reductase inhib itors modify the inflammatory response of human macrophages and endothelial cells infected with Chlamydia Pneumoniae. Circulation,2000,101 ( 15 ) : 1760 - 1763.
  • 6殷跃辉,石伟.他汀类药物抗心房颤动作用[J].心血管病学进展,2008,29(1):141-143. 被引量:9

二级参考文献21

  • 1周自强,胡大一,陈捷,张仁汉,李奎宝,赵秀丽.中国心房颤动现状的流行病学研究[J].中华内科杂志,2004,43(7):491-494. 被引量:1401
  • 2周培荣,张士森,刘玉珍.胺碘酮与辛伐他汀联用治疗阵发性心房颤动的临床研究[J].滨州医学院学报,2007,30(3):183-184. 被引量:7
  • 3Wolf PA ,Abbolt RD,Kannel WB. Atrial fibrillation as an independent risk factor for stroke: the Framingham Study [ J ]. Stroke, 1991,22 ( 8 ) :983-988.
  • 4Benjamin EJ,Wolf PA,D'Agostino RB,et al. Impact of atrial fibrillation on the risk of death : the Framingham heart study [ J ]. Circulation, 1998,98 ( 1 O) : 946- 952.
  • 5Patel AA,White CM ,Shah SA, et al. The relationship between statin use and atrial fibrillation[J]. Curr Med Res Opin,2007,23(5) :1177-1185.
  • 6Tveit A, Grundtvig M, Gtmdersen T, et al. Analysis of pravastatin to prevenl recurrence of atrial fibrillation after electrical cardioversion [ J ]. Am J Cardiol, 2004,93:780-782.
  • 7Demellis J, Panaretou M. Effect of C-reactive protein reduction on paroxysmal atrial fibrillation [ J ]. Am Heart J ,2005,150 : 1064.
  • 8Ozaydin M, Varol E,Aslan SM,et al. Effect of atorvastatin on the recurrence rates of atrial fibrillation after electrical cardioversion[ J]. Am J Cardiol,2006, 97 : 1490-1493.
  • 9Patti G,Chello M ,Candura D,et al. Randomized trial of atorvastatin for reduction of postoperative atrial fibrillation in patients undergoing cardiac surgery:results of the ARMYDA-3 (Atorvastatin for Reduction of MYocardial Dysrhythmia After cardiac surgery) study[ J ]. Circulation ,2006,114 : 1455-1461.
  • 10Lijnen P,Celis H,Fagard R,et al. Influence of cholesterol lowering on plasma membrane lipids and cationic transport systems [ J ]. J Hypertens, 1994,12:59- 64.

共引文献8

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部