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组蛋白去乙酰化酶抑制剂的研究进展 被引量：3

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摘要 核小体是真核生物染色质的基本单位，核小体的中部由4种组蛋白（H2A，H2B，H3，H4）各两分子形成八聚体，周围围绕DNA，尾部为组蛋白H1。核小体表面修饰与基因表达调控联系密切。组蛋白乙酰化是其中一种重要的共价修饰，通过招募染色体构型重建复合体引起染色体构型发生改变。染色体构型改变使高度螺旋的染色质变得相对松弛，便于转录因子与DNA结合。使组蛋白乙酰化的主要是组蛋白乙酰转移酶（histone acetyltransferase，HAT）和组蛋白去乙酰化酶抑制剂（histone deacetylase inhibitors，HDACI）。
作者 白慧颖 胡森 冀文茹
机构地区 内蒙古医学院基础医学院 解放军总医院第一附属医院烧伤研究所休克及器官功能障碍实验室
出处 《感染．炎症．修复》 2009年第3期187-189,共3页 Infection Inflammation Repair
基金 军队医药卫生"十一五"科研基金资助项目(06Z055)
关键词 组蛋白去乙酰化酶抑制剂 组蛋白乙酰转移酶 组蛋白乙酰化 DNA结合 基因表达调控 核小体 染色体 真核生物
分类号 R733.7 [医药卫生—肿瘤] R730.2 [医药卫生—肿瘤]
  • 相关文献

参考文献20

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二级参考文献14

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共引文献1

同被引文献25

  • 1Gonzales ER,Chen H,Munuve RM,et al.Hepatoprotection and lethality rescue by histone deacetylase inhibitor valproic acid in fatal hemorrhagic shock.J Trauma,2008,65(3):554-565.
  • 2Shults C,Sailhamer EA,Li Y,et al.Surviving blood loss without fluid resuscitation.J Trauma,2008,64(3):629-640.
  • 3Li Y,Liu B,Zhao H,et al.Protective effect of suberoylanilide hydroxamic acid against LPS-induced septic shock in rodents.Shock,2009,32(5):517-523.
  • 4Alam HB,Shuja F,Butt MU,et al.Surviving blood loss without blood transfusion in a swine poly-trauma model.Surgery,2009,146(2):325-333.
  • 5Lin T,Alam HB,Chen H,et al.Cardiac histones are substrates of histone deacetylase activity in hemorrhagic shock and resuscitation.Surgery,2006,139 (3):365-376.
  • 6Li Y,Liu B,Sailhamer EA,et al.Cell protective mechanism of valproic acid in lethal hemorrhagic shock.Surgery,2008,144(2):217-224.
  • 7Butt MU,Sailhamer EA,Li Y,et al.Pharmacologic resuscitation:cell protective mechanisms of histone deacetylase inhibition in lethal hemorrhagic shock.J Surg Res,2009,156(2):290-296.
  • 8Fukudome EY,Kochanek AR,Li Y,et al.Pharmacologic resuscitation promotes survival and attenuates hemorrhage-induced activation of extracellular signal-Regulated Kinase 1/2.J Surg Res,2010,163(1):118-126.
  • 9Gonzales ER,Chen H,Munuve RM,et al.Valproic acid prevents hemorrhage-associated lethality and affects the acetylation pattern of cardiac histones.Shock,2006,25(4):395-401.
  • 10Sailhamer EA,Li Y,Smith EJ,et al.Hypoxic "second hit" in leukocytes from trauma patients:modulation of the immune response by histone deacetylase inhibition.Cytokine,2010,49(3):303-311.

引证文献3

二级引证文献5

感染．炎症．修复
2009年 第3期

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