Survivin、VEGF及CD105在结肠癌中的表达及其意义

The Expression and Significance of Survivin,VEGF and CD105 in Colorectal Carcinoma

目的研究生存素(Survivin)、血管内皮生长因子(VEGF)及CD105在结肠癌中的表达,探讨其在肿瘤发生、发展及转移中的作用。方法应用流式细胞技术检测78例结肠癌与40例正常结肠组织中Survivin、VEGF及CD105的表达,分析其在肿瘤中表达的意义及其与结肠癌临床病理特征的关系。结果Survivin、VEGF及CD105在结肠癌中的表达均明显高于正常结肠组织,Survivin、VEGF及CD105的表达与结肠癌的分化程度、浸润深度、Dukes分期及淋巴结转移密切相关,与性别、年龄、肿瘤直径及炎细胞浸润无明显相关。结肠癌中Survivin、VEGF与CD105的表达存在正相关。结论Survivin、VEGF及CD105可能与结肠癌的发生有关,可作为判断预后的指标之一。

Objective To detect the expressions of survivin, vascular endothelial growth factor （VEGF） and CD105 in eolorectal carcinoma, and investigate their relationship in pathogenesis, development and metastasis in colorectal carcinoma. Methods The study included 78 cases of colorectal carcinoma as experimental group and 40 cases of normal tissues as control group. The expressions of Survivin, VEGF and CD105 in different pathological character were analyzed by applying the Flow Cytometry. Results Comparisons of the primary tumors with colorectal carcinoma and normal tissues show that there were significant upregulation of Survivin, VEGF and CD105. The expressions of Survivin, VEGF and CD105 were associated with differentitation, infiltration degree, Dukes stage and lymph node metastasis. There was positive correlationship between Survivin and VEGF, VEGF and CD105, Survivin and CD105 in colorectal carcinoma. Conclusions Survivin, VEGF and CD105 may be correlated with the pathogenesis and development of colorectal carcinoma. The expressions of Survivin, VEGF and CD105 protein may be significant prognostic indicators.